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FGD5 FYVE, RhoGEF and PH domain containing 5 [ Gallus gallus (chicken) ]

Gene ID: 416130, updated on 13-Apr-2026
Symbol
FGD5provided by CGNC
Full Name
FYVE, RhoGEF and PH domain containing 5provided by CGNC
Primary source
CGNC:6483
See related
Ensembl:ENSGALG00010022028
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See FGD5 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
23
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (19967367..20057026, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (20005615..20095275, complement)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2 group C member 2 Neighboring gene protein IQ-DOMAIN 14-like Neighboring gene uncharacterized LOC124417172 Neighboring gene uncharacterized LOC107053907

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
FYVE, RhoGEF and PH domain-containing protein 5

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    19967367..20057026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040646755.2 → XP_040502689.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZLE1, A0A8V0ZTW1
    Related
    ENSGALP00010032276.1, ENSGALT00010053564.1
    Conserved Domains (4) summary
    smart00325
    Location:983 → 1165
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13237
    Location:1439 → 1527
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15792
    Location:1183 → 1305
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:1319 → 1385
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins

  2. XM_004944732.5 → XP_004944789.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2U3H3, E1BQN2
    Related
    ENSGALP00010032271.1, ENSGALT00010053557.1
    Conserved Domains (4) summary
    cd13237
    Location:1483 → 1571
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15792
    Location:1227 → 1349
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:1363 → 1429
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    pfam00621
    Location:1027 → 1208
    RhoGEF; RhoGEF domain

  3. XM_046900214.1 → XP_046756170.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZLE1, A0A8V0ZTW1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    20005615..20095275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040682457.2 → XP_040538391.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZLE1, A0A8V0ZTW1
    Conserved Domains (4) summary
    smart00325
    Location:983 → 1165
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13237
    Location:1439 → 1527
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15792
    Location:1183 → 1305
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:1319 → 1385
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins

  2. XM_040682456.2 → XP_040538390.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2U3H3, E1BQN2
    Conserved Domains (4) summary
    cd13237
    Location:1483 → 1571
    PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
    cd15792
    Location:1227 → 1349
    PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
    cd15742
    Location:1363 → 1429
    FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
    pfam00621
    Location:1027 → 1208
    RhoGEF; RhoGEF domain

  3. XM_046926672.1 → XP_046782628.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZLE1, A0A8V0ZTW1
Nucleotide Protein Strain
Heading Accession and Version

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