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FHIT fragile histidine triad diadenosine triphosphatase [ Gallus gallus (chicken) ]

Gene ID: 416071, updated on 5-Sep-2025
Official Symbol
FHITprovided by CGNC
Official Full Name
fragile histidine triad diadenosine triphosphataseprovided by CGNC
Primary source
CGNC:5420
See related
Ensembl:ENSGALG00010021016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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See FHIT in Genome Data Viewer
Location:
chromosome: 12
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (12341535..12854338, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (12369823..12888194, complement)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene C3orf67 homolog Neighboring gene family with sequence similarity 3, member D Neighboring gene uncharacterized LOC121106601 Neighboring gene uncharacterized LOC121106598 Neighboring gene protein tyrosine phosphatase, receptor type G Neighboring gene microRNA 1550

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Comparative metabolic pathway analysis with special reference to nucleotide metabolism-related genes in chicken primordial germ cells. Rengaraj D, et al. Theriogenology, 2013 Jan 1. PMID 23102846
  2. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. According to microarray and qRT-PCR analyses, the nucleotide metabolism-related gene FHIT was more highly expressed in the chicken primordial germ cells than that of stage X blastoderms.
    Title: Comparative metabolic pathway analysis with special reference to nucleotide metabolism-related genes in chicken primordial germ cells.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables bis(5'-adenosyl)-triphosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in diadenosine triphosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in purine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
bis(5'-adenosyl)-triphosphatase
NP_001264731.2
NP_001264733.1
XP_046755907.1
XP_046755908.1
XP_046755909.1
XP_046755910.1
XP_046755911.1
XP_046755912.1
XP_046755913.1
XP_046755914.1
XP_046755915.1
XP_046755916.1
XP_046782357.1
XP_046782358.1
XP_046782359.1
XP_046782360.1
XP_046782361.1
XP_046782362.1
XP_046782363.1
XP_046782364.1
XP_046782365.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277802.3 → NP_001264731.2  bis(5'-adenosyl)-triphosphatase

    See identical proteins and their annotated locations for NP_001264731.2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000252
    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30
    Conserved Domains (1) summary
    cd01275
    Location:4 → 123
    FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

  2. NM_001277804.3 → NP_001264733.1  bis(5'-adenosyl)-triphosphatase

    See identical proteins and their annotated locations for NP_001264733.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000252
    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30
    Conserved Domains (1) summary
    cd01275
    Location:4 → 123
    FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12341535..12854338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046899953.1 → XP_046755909.1  bis(5'-adenosyl)-triphosphatase isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z9S7, A0A8V0ZFK2
    Related
    ENSGALP00010030039.1, ENSGALT00010050848.1

  2. XM_046899954.1 → XP_046755910.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30
    Related
    ENSGALP00010030036.1, ENSGALT00010050845.1

  3. XM_046899951.1 → XP_046755907.1  bis(5'-adenosyl)-triphosphatase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z9S7, A0A8V0ZMY4
    Related
    ENSGALP00010030033.1, ENSGALT00010050842.1

  4. XM_046899952.1 → XP_046755908.1  bis(5'-adenosyl)-triphosphatase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z9S7, A0A8V0ZMY4

  5. XM_046899958.1 → XP_046755914.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  6. XM_046899956.1 → XP_046755912.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  7. XM_046899959.1 → XP_046755915.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  8. XM_046899957.1 → XP_046755913.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  9. XM_046899955.1 → XP_046755911.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  10. XM_046899960.1 → XP_046755916.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30
    Related
    ENSGALP00010030026.1, ENSGALT00010050835.1

RNA

  1. XR_006931286.1 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12369823..12888194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926402.1 → XP_046782358.1  bis(5'-adenosyl)-triphosphatase isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z9S7, A0A8V0ZFK2

  2. XM_046926403.1 → XP_046782359.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  3. XM_046926401.1 → XP_046782357.1  bis(5'-adenosyl)-triphosphatase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z9S7, A0A8V0ZMY4

  4. XM_046926407.1 → XP_046782363.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  5. XM_046926405.1 → XP_046782361.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  6. XM_046926408.1 → XP_046782364.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  7. XM_046926406.1 → XP_046782362.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  8. XM_046926404.1 → XP_046782360.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

  9. XM_046926409.1 → XP_046782365.1  bis(5'-adenosyl)-triphosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGS3, F1NA30

RNA

  1. XR_006935950.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials