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ARHGEF3 Rho guanine nucleotide exchange factor 3 [ Gallus gallus (chicken) ]

Gene ID: 416000, updated on 13-Apr-2026
Official Symbol
ARHGEF3provided by CGNC
Official Full Name
Rho guanine nucleotide exchange factor 3provided by CGNC
Primary source
CGNC:4085
See related
Ensembl:ENSGALG00010027027
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See ARHGEF3 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (8612110..8725517, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (8639516..8752789, complement)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene coiled-coil domain containing 66 Neighboring gene family with sequence similarity 208 member A Neighboring gene uncharacterized LOC124417171 Neighboring gene interleukin 17 receptor D Neighboring gene HESX homeobox 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
rho guanine nucleotide exchange factor 3
Names
Rho guanine nucleotide exchange factor (GEF) 3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030595.2 → NP_001025766.2  rho guanine nucleotide exchange factor 3

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000252
    UniProtKB/Swiss-Prot
    Q5ZLX4
    UniProtKB/TrEMBL
    F1P5U0
    Related
    ENSGALP00010039835.1, ENSGALT00010065498.1
    Conserved Domains (2) summary
    smart00325
    Location:126 → 302
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd10572
    Location:316 → 448
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    8612110..8725517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040646223.2 → XP_040502157.1  rho guanine nucleotide exchange factor 3 isoform X6

    UniProtKB/TrEMBL
    A0A8V1A1T6, A0A8V1AEA9
    Related
    ENSGALP00010039842.1, ENSGALT00010065513.1
    Conserved Domains (2) summary
    smart00325
    Location:148 → 324
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd10572
    Location:338 → 470
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain

  2. XM_015293068.4 → XP_015148554.2  rho guanine nucleotide exchange factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8V1A6U7, A0A8V1AEB2
    Related
    ENSGALP00010039843.1, ENSGALT00010065514.1
    Conserved Domains (2) summary
    smart00325
    Location:180 → 356
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd10572
    Location:370 → 502
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain

  3. XM_040646221.2 → XP_040502155.1  rho guanine nucleotide exchange factor 3 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A6U7
    Conserved Domains (2) summary
    smart00325
    Location:200 → 376
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd10572
    Location:390 → 522
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain

  4. XM_046899898.1 → XP_046755854.1  rho guanine nucleotide exchange factor 3 isoform X4

    UniProtKB/TrEMBL
    A0A8V1A6U7

  5. XM_046899897.1 → XP_046755853.1  rho guanine nucleotide exchange factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8V1A6U7

  6. XM_015293069.4 → XP_015148555.1  rho guanine nucleotide exchange factor 3 isoform X5

    UniProtKB/TrEMBL
    A0A8V1AEA9
    Conserved Domains (2) summary
    cd10572
    Location:355 → 487
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
    pfam00621
    Location:165 → 341
    RhoGEF; RhoGEF domain

  7. XM_015293070.3 → XP_015148556.1  rho guanine nucleotide exchange factor 3 isoform X7

    UniProtKB/TrEMBL
    A0A8V1A1T2, A0A8V1A9D5
    Related
    ENSGALP00010039837.1, ENSGALT00010065501.1
    Conserved Domains (2) summary
    cd10572
    Location:316 → 448
    PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain
    pfam00621
    Location:126 → 302
    RhoGEF; RhoGEF domain

RNA

  1. XR_006931285.1 RNA Sequence

  2. XR_006931284.1 RNA Sequence

  3. XR_006931283.1 RNA Sequence

  4. XR_005839154.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    8639516..8752789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926301.1 → XP_046782257.1  rho guanine nucleotide exchange factor 3 isoform X6

    UniProtKB/TrEMBL
    A0A8V1A1T6, A0A8V1AEA9

  2. XM_046926298.1 → XP_046782254.1  rho guanine nucleotide exchange factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8V1A6U7, A0A8V1AEB2

  3. XM_046926296.1 → XP_046782252.1  rho guanine nucleotide exchange factor 3 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A6U7

  4. XM_046926299.1 → XP_046782255.1  rho guanine nucleotide exchange factor 3 isoform X4

    UniProtKB/TrEMBL
    A0A8V1A6U7

  5. XM_046926297.1 → XP_046782253.1  rho guanine nucleotide exchange factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8V1A6U7

  6. XM_046926300.1 → XP_046782256.1  rho guanine nucleotide exchange factor 3 isoform X5

    UniProtKB/TrEMBL
    A0A8V1AEA9

  7. XM_046926302.1 → XP_046782258.1  rho guanine nucleotide exchange factor 3 isoform X7

    UniProtKB/TrEMBL
    A0A8V1A1T2, A0A8V1A9D5

RNA

  1. XR_006935943.1 RNA Sequence

  2. XR_006935942.1 RNA Sequence

  3. XR_006935944.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZLX4.1 GenPept UniProtKB/Swiss-Prot:Q5ZLX4

Gene LinkOut

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