Format

Send to:

Choose Destination

ARSF arylsulfatase F [ Homo sapiens (human) ]

Gene ID: 416, updated on 8-Jul-2021

Summary

Official Symbol
ARSFprovided by HGNC
Official Full Name
arylsulfatase Fprovided by HGNC
Primary source
HGNC:HGNC:721
See related
Ensembl:ENSG00000062096 MIM:300003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASF
Summary
This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of the subfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting that they are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone and cartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jan 2011]
Expression
Biased expression in kidney (RPKM 3.3), skin (RPKM 2.1) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ARSF in Genome Data Viewer
Location:
Xp22.33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (3040234..3112727)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (2958275..3030768)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene arylsulfatase L Neighboring gene arylsulfatase family member H Neighboring gene RNA, 7SL, cytoplasmic 578, pseudogene Neighboring gene ribosomal protein S24 pseudogene 21 Neighboring gene long intergenic non-protein coding RNA 1546

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arylsulfatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
arylsulfatase F
NP_001188467.1
NP_001188468.1
NP_004033.2
XP_011543824.1
XP_011543825.1
XP_011543826.1
XP_016885016.1
XP_016885017.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012822.2 RefSeqGene

    Range
    31566..77496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201538.2NP_001188467.1  arylsulfatase F precursor

    See identical proteins and their annotated locations for NP_001188467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC112653, BP274206, BP277542, BX107362, DA628671
    Consensus CDS
    CCDS14123.1
    UniProtKB/Swiss-Prot
    P54793
    Conserved Domains (2) summary
    COG3119
    Location:27528
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:29553
    ALP_like; alkaline phosphatases and sulfatases
  2. NM_001201539.2NP_001188468.1  arylsulfatase F precursor

    See identical proteins and their annotated locations for NP_001188468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC112653, BC022389
    Consensus CDS
    CCDS14123.1
    UniProtKB/Swiss-Prot
    P54793
    Related
    ENSP00000370519.1, ENST00000381127.6
    Conserved Domains (2) summary
    COG3119
    Location:27528
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:29553
    ALP_like; alkaline phosphatases and sulfatases
  3. NM_004042.5NP_004033.2  arylsulfatase F precursor

    See identical proteins and their annotated locations for NP_004033.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest variant. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC112653, DA156994, X97868
    Consensus CDS
    CCDS14123.1
    UniProtKB/Swiss-Prot
    P54793
    Related
    ENSP00000352319.2, ENST00000359361.2
    Conserved Domains (2) summary
    COG3119
    Location:27528
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:29553
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    3040234..3112727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029527.1XP_016885016.1  arylsulfatase F isoform X3

  2. XM_011545522.1XP_011543824.1  arylsulfatase F isoform X1

    Conserved Domains (2) summary
    COG3119
    Location:44560
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:46570
    ALP_like; alkaline phosphatases and sulfatases
  3. XM_011545523.1XP_011543825.1  arylsulfatase F isoform X2

    Conserved Domains (2) summary
    COG3119
    Location:44531
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:46541
    ALP_like; alkaline phosphatases and sulfatases
  4. XM_011545524.1XP_011543826.1  arylsulfatase F isoform X4

    Conserved Domains (2) summary
    COG3119
    Location:44194
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:46425
    ALP_like; alkaline phosphatases and sulfatases
  5. XM_017029528.1XP_016885017.1  arylsulfatase F isoform X5

Support Center