FANCD2 Fanconi anemia complementation group D2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: FANCD2provided by CGNC
Full Name: Fanconi anemia complementation group D2provided by CGNC
Primary source: CGNC:2720
See related: Ensembl:ENSGALG00010027361
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	12	NC_052543.1 (2943463..2989540, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	12	NC_052584.1 (2982606..3028537, complement)

Chromosome 12 - NC_052543.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.
Title: FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.
FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells, with high mutation rates at the common chromosomal fragile sites gene PARK2.
Title: FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells.
Collectively, the FANCI-FANCD2 complex-mediated stabilization of the RAD51 nucleoprotein filament may function to prevent destructive DNA degradation by exonucleases during replication and at stalled replication forks.
Title: FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end.
To avoid genome instability, translesion DNA polymerase eta foci do not colocalize with TopBP1 or FANCD2 in mitosis.
Title: TopBP1-mediated DNA processing during mitosis.
Residual FANCD2 monoubiquitination activity is retained in cells defective for other Fanconi anemia core complex subunits.
Title: The genetic and biochemical basis of FANCD2 monoubiquitination.
FANCD2 possesses nucleosome-assembly activity in vitro and FANCD2-FANCI may regulate chromatin dynamics during DNA repair
Title: Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair.
results indicate Fanconi anemia(FA)pathway promotes homologous recombination (HR)repair of DNA double-strand breaks(DSBs) by counteracting Ku70; findings suggest that FANCD2 modifies the DSBs to prevent Ku70 from binding and subverting HR
Title: Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway.
This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination.
Title: Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.
The assembly of the FA core complex and the subcellular localization of UBE2T in the regulation of FANCD2 monoubiquitination, is studied.
Title: UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.
FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination
Title: Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA polymerase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair involved in meiotic recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in homologous chromosome pairing at meiosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in interstrand cross-link repair	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic intra-S DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in condensed chromosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: Fanconi anemia group D2 protein

Names: Protein FACD2; fanconi anemia protein FANCD2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039261.5 → NP_001034350.3 Fanconi anemia group D2 protein

Status: VALIDATED

Source sequence(s)

JAENSK010000251

UniProtKB/Swiss-Prot

Q68Y81

Related

ENSGALP00010040597.1, ENSGALT00010066331.1

Conserved Domains (1) summary

cd11721
Location:92 → 1403

FANCD2; Fanconi anemia D2 protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2943463..2989540 complement

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GenBank, FASTA, Sequence Viewer (Graphics)