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Past1 Putative Achaete Scute Target 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41569, updated on 23-Jul-2026
Official Symbol
Past1provided by FlyBase
Official Full Name
Putative Achaete Scute Target 1provided by FlyBase
Primary source
FLYBASE:FBgn0016693
Locus tag
Dmel_CG6148
See related
AllianceGenome:FB:FBgn0016693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6148; CG66148; dEHD; dEHD1; Dmel\CG6148; Ehd; PAST; Past-1; PAST-1; past1; PAST1
Summary
Predicted to enable GTP binding activity and calcium ion binding activity. Involved in several processes, including compound eye photoreceptor cell differentiation; germ cell development; and imaginal disc-derived wing morphogenesis. Located in cell cortex and subsynaptic reticulum. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; gut section; and larval muscle cell. Orthologous to several human genes including EHD1 (EH domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Past1 in Genome Data Viewer
Location:
87C6-87C6; 3-52 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12697322..12704875)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8523044..8530597)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 1 Neighboring gene uncharacterized protein Neighboring gene Ninjurin C Neighboring gene uncharacterized protein Neighboring gene DNA polymerase theta Neighboring gene Malic enzyme

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Past1 Modulates Drosophila Eye Development. Dorot O, et al. PLoS One, 2017. PMID 28060904, Free PMC Article
  2. An early endosome-derived retrograde trafficking pathway promotes secretory granule maturation. Ma CJ, et al. J Cell Biol, 2020 Mar 2. PMID 32045479, Free PMC Article
  3. The Wolbachia WalE1 effector alters Drosophila endocytosis. Martin M, et al. PLoS Pathog, 2024 Mar. PMID 38547310, Free PMC Article
  4. The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic function. Koles K, et al. Mol Biol Cell, 2015 Sep 15. PMID 26202464, Free PMC Article
  5. The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Smith CA, et al. Mol Biol Cell, 2004 Aug. PMID 15155807, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic interaction was found between Past1 and members of the Notch signaling pathway, suggesting a role for Past1 in this developmentally crucial signaling pathway.
    Title: Drosophila Past1 is involved in endocytosis and is required for germline development and survival of the adult fly.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Preferred Names
putative achaete scute target 1
Names
CG6148-PA
CG6148-PB
EH domain containing protein
Past1-PA
Past1-PB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12697322..12704875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169478.2 → NP_731737.1  putative achaete scute target 1, isoform A

    See identical proteins and their annotated locations for NP_731737.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSM3, Q8IGN0, Q8T8W3
    Related
    FBpp0082123
    Conserved Domains (4) summary
    smart00027
    Location:446 → 538
    EH; Eps15 homology domain
    cd09913
    Location:63 → 303
    EHD; Eps15 homology domain (EHD), C-terminal domain
    pfam16880
    Location:27 → 59
    EHD_N; N-terminal EH-domain containing protein
    pfam18150
    Location:291 → 397
    DUF5600; Domain of unknown function (DUF5600)

  2. NM_079608.3 → NP_524332.2  putative achaete scute target 1, isoform B

    See identical proteins and their annotated locations for NP_524332.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSM2, Q8IGN0, Q8T6I0, Q9VG34
    Related
    FBpp0082124
    Conserved Domains (4) summary
    smart00027
    Location:440 → 532
    EH; Eps15 homology domain
    cd09913
    Location:57 → 297
    EHD; Eps15 homology domain (EHD), C-terminal domain
    pfam16880
    Location:21 → 53
    EHD_N; N-terminal EH-domain containing protein
    pfam18150
    Location:285 → 391
    DUF5600; Domain of unknown function (DUF5600)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGN0 Q8IGN0
Q8T6I0 Q8T6I0
Q8T8W3 Q8T8W3
Q94919 Q94919

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