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RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 [ Gallus gallus (chicken) ]

Gene ID: 415578, updated on 13-Apr-2026
Symbol
RASGRF1provided by CGNC
Full Name
Ras protein specific guanine nucleotide releasing factor 1provided by CGNC
Primary source
CGNC:6258
See related
Ensembl:ENSGALG00010016415
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See RASGRF1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
27
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (19957393..19976419, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (19821220..19840318, complement)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene Bloom syndrome RecQ like helicase Neighboring gene cathepsin H Neighboring gene uncharacterized LOC121111640 Neighboring gene microRNA mir-184b Neighboring gene microRNA 184 Neighboring gene ankyrin repeat domain 34C

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
ras-specific guanine nucleotide-releasing factor 1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    19957393..19976419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015292195.3 → XP_015147681.2  ras-specific guanine nucleotide-releasing factor 1 isoform X2

    Conserved Domains (6) summary
    cd06224
    Location:626 → 676
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:1004 → 1240
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00325
    Location:244 → 425
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19 → 154
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    cl02520
    Location:908 → 977
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431 → 582
    PH-like; Pleckstrin homology-like domain

  2. XM_003641866.5 → XP_003641914.2  ras-specific guanine nucleotide-releasing factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YW34
    Related
    ENSGALP00010022829.1, ENSGALT00010039551.1
    Conserved Domains (6) summary
    cd06224
    Location:639 → 689
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:1017 → 1253
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00325
    Location:244 → 425
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19 → 154
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    cl02520
    Location:921 → 990
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431 → 582
    PH-like; Pleckstrin homology-like domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    19821220..19840318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040680334.2 → XP_040536268.1  ras-specific guanine nucleotide-releasing factor 1 isoform X2

    Conserved Domains (6) summary
    smart00147
    Location:1004 → 1240
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00325
    Location:244 → 425
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19 → 154
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00618
    Location:621 → 669
    RasGEF_N; RasGEF N-terminal motif
    cl02520
    Location:908 → 977
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431 → 582
    PH-like; Pleckstrin homology-like domain

  2. XM_040680333.2 → XP_040536267.1  ras-specific guanine nucleotide-releasing factor 1 isoform X1

    Conserved Domains (6) summary
    smart00147
    Location:1017 → 1253
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00325
    Location:244 → 425
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19 → 154
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00618
    Location:634 → 682
    RasGEF_N; RasGEF N-terminal motif
    cl02520
    Location:921 → 990
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cl17171
    Location:431 → 582
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version

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