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FANCI Fanconi anemia complementation group I [ Gallus gallus (chicken) ]

Gene ID: 415491, updated on 5-Sep-2025
Symbol
FANCIprovided by CGNC
Full Name
Fanconi anemia complementation group Iprovided by CGNC
Primary source
CGNC:5028
See related
Ensembl:ENSGALG00010016181
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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See FANCI in Genome Data Viewer
Location:
chromosome: 10
Exon count:
37
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (12964865..12988611, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (12842736..12866467, complement)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054204 Neighboring gene microRNA mir-9b-1 Neighboring gene microRNA mir-9-3 Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene DNA polymerase gamma, catalytic subunit Neighboring gene retinaldehyde binding protein 1 Neighboring gene abhydrolase domain containing 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair. Alcón P, et al. Nat Struct Mol Biol, 2020 Mar. PMID 32066963, Free PMC Article
  2. DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI. Sato K, et al. Nucleic Acids Res, 2012 May. PMID 22287633, Free PMC Article
  3. FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end. Sato K, et al. Nucleic Acids Res, 2016 Dec 15. PMID 27694619, Free PMC Article
  4. Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair. Sato K, et al. EMBO J, 2012 Aug 29. PMID 22828868, Free PMC Article
  5. FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair. Unno J, et al. Cell Rep, 2014 May 22. PMID 24794430

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.
    Title: FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.
  2. Collectively, the FANCI-FANCD2 complex-mediated stabilization of the RAD51 nucleoprotein filament may function to prevent destructive DNA degradation by exonucleases during replication and at stalled replication forks.
    Title: FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end.
  3. FANCD2 possesses nucleosome-assembly activity in vitro and FANCD2-FANCI may regulate chromatin dynamics during DNA repair
    Title: Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA polymerase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
Fanconi anemia group I protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114851.2 → NP_001108323.2  Fanconi anemia group I protein

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000245
    UniProtKB/Swiss-Prot
    B0I564
    UniProtKB/TrEMBL
    A0A8V0YNA7
    Related
    ENSGALP00010022478.1, ENSGALT00010038894.1
    Conserved Domains (1) summary
    cd11720
    Location:41 → 1295
    FANCI; Fanconi anemia I protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12964865..12988611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015292007.4 → XP_015147493.2  Fanconi anemia group I protein isoform X1

    UniProtKB/Swiss-Prot
    B0I564
    Conserved Domains (1) summary
    cd11720
    Location:41 → 1294
    FANCI; Fanconi anemia I protein

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12842736..12866467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924874.1 → XP_046780830.1  Fanconi anemia group I protein isoform X1

    UniProtKB/Swiss-Prot
    B0I564
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0I564.1 GenPept UniProtKB/Swiss-Prot:B0I564

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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