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USP8 ubiquitin specific peptidase 8 [ Gallus gallus (chicken) ]

Gene ID: 415451, updated on 13-Apr-2026
Symbol
USP8provided by CGNC
Full Name
ubiquitin specific peptidase 8provided by CGNC
Primary source
CGNC:4401
See related
Ensembl:ENSGALG00010017377
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See USP8 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (10852957..10878476, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (10726428..10751942, complement)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene microRNA 6596 Neighboring gene transient receptor potential cation channel subfamily M member 7 Neighboring gene GA binding protein transcription factor beta subunit 1 Neighboring gene histidine decarboxylase Neighboring gene glycine amidinotransferase

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosome organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K48-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extrinsic component of endosome membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extrinsic component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
ubiquitin carboxyl-terminal hydrolase 8
XP_015147503.2
XP_015147505.2
XP_015147506.2
XP_040536212.1
XP_040536213.1
XP_040536214.1
XP_040536215.1
XP_040536216.1
XP_040536217.1
XP_040536218.1
XP_040536219.1
XP_040536220.1
XP_040562690.1
XP_040562691.1
XP_040562692.1
XP_040562693.1
XP_040562694.1
XP_040562695.1
XP_046755086.1
XP_046755087.1
XP_046780978.1
XP_046780979.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10852957..10878476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040706761.2 → XP_040562695.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 571
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:197 → 309
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:743 → 923
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:745 → 1074
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  2. XM_040706757.2 → XP_040562691.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 628
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:774 → 954
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:776 → 1105
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  3. XM_046899131.1 → XP_046755087.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9

  4. XM_040706760.2 → XP_040562694.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 571
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:197 → 309
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:743 → 923
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:745 → 1074
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  5. XM_015292019.4 → XP_015147505.2  ubiquitin carboxyl-terminal hydrolase 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z7U9, A0A8V0Z7V4
    Related
    ENSGALP00010024541.1, ENSGALT00010041939.1
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 627
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:197 → 309
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:773 → 953
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:775 → 1104
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  6. XM_015292020.4 → XP_015147506.2  ubiquitin carboxyl-terminal hydrolase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z0V1, A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 572
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:744 → 924
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:746 → 1075
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  7. XM_015292017.4 → XP_015147503.2  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Related
    ENSGALP00010024536.1, ENSGALT00010041932.1
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 628
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:774 → 954
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:776 → 1105
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  8. XM_040706758.2 → XP_040562692.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z7U9, A0A8V0Z7V4
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 627
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:197 → 309
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:773 → 953
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:775 → 1104
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  9. XM_040706759.2 → XP_040562693.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z0V1, A0A8V0Z7U9
    Related
    ENSGALP00010024539.1, ENSGALT00010041935.1
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 572
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:744 → 924
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:746 → 1075
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  10. XM_040706756.2 → XP_040562690.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 628
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:774 → 954
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:776 → 1105
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  11. XM_046899130.1 → XP_046755086.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10726428..10751942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040680286.2 → XP_040536220.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 571
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:197 → 309
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:743 → 923
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:745 → 1074
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  2. XM_040680280.2 → XP_040536214.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 628
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:774 → 954
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:776 → 1105
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  3. XM_046925023.1 → XP_046780979.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9

  4. XM_040680285.2 → XP_040536219.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 571
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:197 → 309
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:743 → 923
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:745 → 1074
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  5. XM_040680281.2 → XP_040536215.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 627
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:197 → 309
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:773 → 953
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:775 → 1104
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  6. XM_040680283.2 → XP_040536217.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 572
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:744 → 924
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:746 → 1075
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  7. XM_040680278.2 → XP_040536212.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 628
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:774 → 954
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:776 → 1105
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  8. XM_040680282.2 → XP_040536216.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 627
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:197 → 309
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:773 → 953
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:775 → 1104
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  9. XM_040680284.2 → XP_040536218.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 572
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:744 → 924
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:746 → 1075
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  10. XM_040680279.2 → XP_040536213.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9
    Conserved Domains (4) summary
    PTZ00121
    Location:19 → 628
    PTZ00121; MAEBL; Provisional
    smart00450
    Location:198 → 310
    RHOD; Rhodanese Homology Domain
    COG5560
    Location:774 → 954
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:776 → 1105
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  11. XM_046925022.1 → XP_046780978.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z7U9
Nucleotide Protein Strain
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