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RORA RAR related orphan receptor A [ Gallus gallus (chicken) ]

Gene ID: 415377, updated on 14-Feb-2019

Summary

Symbol
RORAprovided by CGNC
Full Name
RAR related orphan receptor Aprovided by CGNC
Primary source
CGNC:2749
See related
Ensembl:ENSGALG00000003759
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
RORalpha1
Summary
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
Orthologs

Genomic context

See RORA in Genome Data Viewer
Location:
chromosome: 10
Exon count:
14
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 10 NC_006097.5 (5137494..5492385)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 10 NC_006097.4 (4625085..4980804)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 10 NC_006097.3 (4187635..4536712)

Chromosome 10 - NC_006097.5Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13 homolog C Neighboring gene uncharacterized LOC101750100 Neighboring gene uncharacterized LOC107052149 Neighboring gene interactor of little elongation complex ELL subunit 2 Neighboring gene annexin A2

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...

General gene information

Markers

Homology

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289887.1NP_001276816.1  nuclear receptor ROR-alpha

    Status: PROVISIONAL

    Source sequence(s)
    AADN05000047
    Related
    ENSGALP00000072022.1, ENSGALT00000102446.1
    Conserved Domains (2) summary
    cd06939
    Location:273512
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:67161
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006097.5 Reference GRCg6a Primary Assembly

    Range
    5137494..5492385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015278887.2XP_015134373.1  nuclear receptor ROR-alpha isoform X2

    Conserved Domains (2) summary
    cd06939
    Location:273512
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:67161
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
  2. XM_004943750.3XP_004943807.2  nuclear receptor ROR-alpha isoform X1

    Conserved Domains (2) summary
    cd06939
    Location:384621
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:239333
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
  3. XM_015278888.2XP_015134374.1  nuclear receptor ROR-alpha isoform X3

    Related
    ENSGALP00000005957.5, ENSGALT00000005967.6
    Conserved Domains (2) summary
    cd06939
    Location:217456
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:11105
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
  4. XM_015278889.2XP_015134375.1  nuclear receptor ROR-alpha isoform X4

    Conserved Domains (2) summary
    cd06939
    Location:188427
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cl02596
    Location:1076
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
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