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MITF melanocyte inducing transcription factor [ Sus scrofa (pig) ]

Gene ID: 414902, updated on 3-Dec-2024

Summary

Official Symbol
MITFprovided by VGNC
Official Full Name
melanocyte inducing transcription factorprovided by VGNC
Primary source
VGNC:VGNC:90243
See related
Ensembl:ENSSSCG00000011514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in heart (RPKM 5.0), subcutaneous adipose (RPKM 2.2) and 8 other tissues See more
Orthologs
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Genomic context

See MITF in Genome Data Viewer
Location:
chromosome: 13
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (51177356..51422096)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (56593519..56594255, complement)

Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene FERM domain containing 4B Neighboring gene uncharacterized LOC110256517 Neighboring gene uncharacterized LOC110256268 Neighboring gene MyoD family inhibitor domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General protein information

Preferred Names
microphthalmia-associated transcription factor
Names
melanogenesis associated transcription factor
microphtalmia-associated transcription factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038001.2NP_001033090.1  microphthalmia-associated transcription factor isoform 3

    See identical proteins and their annotated locations for NP_001033090.1

    Status: VALIDATED

    Source sequence(s)
    AEMK02000086
    UniProtKB/TrEMBL
    A0A4X1V9Y0, A0A8D0WSB6, A0A8D1D803, Q4LE87
    Related
    ENSSSCP00000068733.1, ENSSSCT00000078093.2
    Conserved Domains (3) summary
    cd00083
    Location:196256
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:284397
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:1187
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  2. NM_001315782.2NP_001302711.2  microphthalmia-associated transcription factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AEMK02000086
    UniProtKB/TrEMBL
    A0A8D0WN30, A0A8D1BHD2, A0A8D1UQM7, D2JUK2, I3LTE0
  3. NM_001425284.1NP_001412213.1  microphthalmia-associated transcription factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AEMK02000086
    UniProtKB/TrEMBL
    A0A0B8RSL1, A0A287B431, A0A8D0WS60, A0A8D1D7M8, A0A8D1RBX1

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

    Range
    51177356..51422096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021068590.1XP_020924249.1  microphthalmia-associated transcription factor isoform X8

    UniProtKB/TrEMBL
    A0A8D1A1T9
    Conserved Domains (3) summary
    cd00083
    Location:257317
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:345464
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:4142
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  2. XM_021068591.1XP_020924250.1  microphthalmia-associated transcription factor isoform X9

    UniProtKB/TrEMBL
    A0A8D1UQN8
    Conserved Domains (3) summary
    cd00083
    Location:253313
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:341460
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56138
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  3. XM_021068583.1XP_020924242.1  microphthalmia-associated transcription factor isoform X1

    UniProtKB/TrEMBL
    A0A4X1V9W8, D2JUK1
    Conserved Domains (3) summary
    cd00083
    Location:309369
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:397516
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56194
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  4. XM_021068592.1XP_020924251.1  microphthalmia-associated transcription factor isoform X10

    UniProtKB/TrEMBL
    A0A8D1UQN8
    Conserved Domains (3) summary
    cd00083
    Location:233293
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:321440
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56118
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  5. XM_021068584.1XP_020924243.1  microphthalmia-associated transcription factor isoform X2

    UniProtKB/TrEMBL
    A0A4X1V9W8
    Conserved Domains (3) summary
    cd00083
    Location:308368
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:396515
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:55193
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  6. XM_021068585.1XP_020924244.1  microphthalmia-associated transcription factor isoform X3

    Related
    ENSSSCP00000051180.1, ENSSSCT00000046150.2
    Conserved Domains (3) summary
    cd00083
    Location:303363
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:391510
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56194
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  7. XM_021068587.1XP_020924246.1  microphthalmia-associated transcription factor isoform X5

    UniProtKB/TrEMBL
    A0A8D0WN30, A0A8D1BHD2, D2JUK2
    Conserved Domains (3) summary
    cd00083
    Location:292352
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:380499
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:39177
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  8. XM_021068586.1XP_020924245.1  microphthalmia-associated transcription factor isoform X4

    Related
    ENSSSCP00000027385.2, ENSSSCT00000025535.4
    Conserved Domains (3) summary
    cd00083
    Location:293353
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:381500
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:40178
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  9. XM_021068589.1XP_020924248.1  microphthalmia-associated transcription factor isoform X7

    UniProtKB/TrEMBL
    A0A8D1UQW3
    Conserved Domains (3) summary
    cd00083
    Location:278338
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:366485
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:25163
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  10. XM_021068588.1XP_020924247.1  microphthalmia-associated transcription factor isoform X6

    UniProtKB/TrEMBL
    A0A8D0WN30, A0A8D1BHD2, D2JUK2
    Conserved Domains (3) summary
    cd00083
    Location:287347
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:375494
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:40178
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  11. XM_013981884.2XP_013837338.2  microphthalmia-associated transcription factor isoform X11

    UniProtKB/TrEMBL
    A0A4X1V9Y0, A0A8D0WSB6, A0A8D1D803, A0A8D1UQU3, D2JUK3
    Related
    ENSSSCP00000012271.2, ENSSSCT00000012600.2
    Conserved Domains (3) summary
    cd00083
    Location:202262
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:290409
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:1187
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
  12. XM_021068593.1XP_020924252.1  microphthalmia-associated transcription factor isoform X12

    UniProtKB/TrEMBL
    A0A4X1V9Y0, A0A8D0WSB6, A0A8D1D803
    Conserved Domains (3) summary
    cd00083
    Location:140200
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:228347
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:1131
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus