U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zyg11b zyg-ll family member B, cell cycle regulator [ Mus musculus (house mouse) ]

Gene ID: 414872, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Zyg11bprovided by MGI
Official Full Name
zyg-ll family member B, cell cycle regulatorprovided by MGI
Primary source
MGI:MGI:2685277
See related
Ensembl:ENSMUSG00000034636 AllianceGenome:MGI:2685277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm431; D4Mgi23; mKIAA1730; 1110046I03Rik; 2810482G21Rik
Summary
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human ZYG11B (zyg-11 family member B, cell cycle regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.5), whole brain E14.5 (RPKM 12.1) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zyg11b in Genome Data Viewer
Location:
4 C7; 4 50.35 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108084947..108158276, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108227755..108301125, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene enoyl Coenzyme A hydratase domain containing 2 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene STARR-seq mESC enhancer starr_11034 Neighboring gene predicted gene, 54249 Neighboring gene STARR-positive B cell enhancer ABC_E2701 Neighboring gene STARR-seq mESC enhancer starr_11037 Neighboring gene STARR-seq mESC enhancer starr_11038 Neighboring gene STARR-positive B cell enhancer ABC_E11249 Neighboring gene STARR-positive B cell enhancer ABC_E10246 Neighboring gene STARR-positive B cell enhancer ABC_E7979 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:108000774-108000883 Neighboring gene STARR-positive B cell enhancer ABC_E2702 Neighboring gene cytochrome c oxidase assembly factor 7 Neighboring gene predicted gene, 46889 Neighboring gene predicted gene, 54250

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ13456

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein zyg-11 homolog B
Names
zyg-ll homolog B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033634.4 → NP_001028806.2  protein zyg-11 homolog B isoform 1

    See identical proteins and their annotated locations for NP_001028806.2

    Status: VALIDATED

    Source sequence(s)
    AL627238, BX293563
    Consensus CDS
    CCDS18448.1
    UniProtKB/Swiss-Prot
    B9EID5, Q148T6, Q3TM33, Q3TMB0, Q3TRM3, Q3UFA3, Q3UFS0, Q80TA0
    Related
    ENSMUSP00000043844.7, ENSMUST00000043616.7
    Conserved Domains (3) summary
    cd00020
    Location:493 → 611
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00116
    Location:177 → 299
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:188 → 213
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. NM_001426993.1 → NP_001413922.1  protein zyg-11 homolog B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627238, BX293563

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    108084947..108158276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UFS0.2 GenPept UniProtKB/Swiss-Prot:Q3UFS0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous