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Zyg11b zyg-ll family member B, cell cycle regulator [ Mus musculus (house mouse) ]

Gene ID: 414872, updated on 26-Sep-2022

Summary

Official Symbol
Zyg11bprovided by MGI
Official Full Name
zyg-ll family member B, cell cycle regulatorprovided by MGI
Primary source
MGI:MGI:2685277
See related
Ensembl:ENSMUSG00000034636 AllianceGenome:MGI:2685277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm431; D4Mgi23; mKIAA1730; 1110046I03Rik; 2810482G21Rik
Summary
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human ZYG11B (zyg-11 family member B, cell cycle regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.5), whole brain E14.5 (RPKM 12.1) and 26 other tissues See more
Orthologs
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Genomic context

See Zyg11b in Genome Data Viewer
Location:
4; 4 C7
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108084952..108158330, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108227755..108301125, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene enoyl Coenzyme A hydratase domain containing 2 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene predicted gene, 54249 Neighboring gene cytochrome c oxidase assembly factor 7 Neighboring gene predicted gene, 46889 Neighboring gene predicted gene, 54250

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13456

General protein information

Preferred Names
protein zyg-11 homolog B
Names
zyg-ll homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033634.3NP_001028806.2  protein zyg-11 homolog B

    See identical proteins and their annotated locations for NP_001028806.2

    Status: VALIDATED

    Source sequence(s)
    AK166031, AL627238, BX293563
    Consensus CDS
    CCDS18448.1
    UniProtKB/Swiss-Prot
    Q3UFS0, Q80TA0
    Related
    ENSMUSP00000043844.7, ENSMUST00000043616.7
    Conserved Domains (3) summary
    cd00020
    Location:493611
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00116
    Location:177299
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:188213
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    108084952..108158330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503213.5XP_006503276.1  protein zyg-11 homolog B isoform X1

    Conserved Domains (2) summary
    sd00034
    Location:108133
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl39015
    Location:97219
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...