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B2M beta-2-microglobulin [ Gallus gallus (chicken) ]

Gene ID: 414830, updated on 5-Sep-2025
Symbol
B2Mprovided by CGNC
Full Name
beta-2-microglobulinprovided by CGNC
Primary source
CGNC:1542
See related
Ensembl:ENSGALG00010023281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03
Orthologs
human mouse all
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See B2M in Genome Data Viewer
Location:
chromosome: 10
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (1355773..1358713)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (1229585..1232518)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 22 Neighboring gene sorting nexin 1 Neighboring gene PAT1 homolog 2 Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene ribosomal protein S17 Neighboring gene cytoplasmic polyadenylation element binding protein 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression kinetics of chicken β2-microglobulin and Class I MHC in vitro and in vivo during Marek's disease viral infections. Yu C, et al. Vet Res Commun, 2013 Dec. PMID 23918553
  2. The chicken beta 2-microglobulin gene is located on a non-major histocompatibility complex microchromosome: a small, G+C-rich gene with X and Y boxes in the promoter. Riegert P, et al. Proc Natl Acad Sci U S A, 1996 Feb 6. PMID 8577748, Free PMC Article
  3. Amino acid sequences and structures of chicken and turkey beta 2-microglobulin. Welinder KG, et al. Mol Immunol, 1991 Jan-Feb. PMID 2011126
  4. Structures and homology modeling of chicken major histocompatibility complex protein class I (BF2 and beta2m). Yan RQ, et al. Mol Immunol, 2006 Mar. PMID 16112197
  5. Different features of the MHC class I heterodimer have evolved at different rates. Chicken B-F and beta 2-microglobulin sequences reveal invariant surface residues. Kaufman J, et al. J Immunol, 1992 Mar 1. PMID 1538136

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the expression levels of Class I MHC and beta2m genes were upregulated during early Marek's disease viral infections in comparison to control cells
    Title: Expression kinetics of chicken β2-microglobulin and Class I MHC in vitro and in vivo during Marek's disease viral infections.
  2. five new BF2 groups and a new beta(2)m group exist in the three Chinese chicken lines
    Title: Characterization of BF2 and beta2m in three Chinese chicken lines.
  3. The two-dimensional (2D) and three-dimensional (3D) structures of chicken major histocompatibility complex (MHC) class I protein (BF2 and beta2m)were elucidated.
    Title: Structures and homology modeling of chicken major histocompatibility complex protein class I (BF2 and beta2m).
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MHC class I protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
beta-2-microglobulin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001750.4 → NP_001001750.2  beta-2-microglobulin precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000245
    UniProtKB/Swiss-Prot
    P21611, Q5W922
    UniProtKB/TrEMBL
    Q6L754, Q6L756
    Related
    ENSGALP00010034517.1, ENSGALT00010056777.1
    Conserved Domains (1) summary
    cd05770
    Location:23 → 116
    IgC1_beta2m; Class I major histocompatibility complex (MHC) beta-2-microglobulin; member of the C1-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1355773..1358713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1229585..1232518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21611.3 GenPept UniProtKB/Swiss-Prot:P21611

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Research Materials
Miscellaneous