CD74 CD74 molecule [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CD74provided by CGNC
Official Full Name: CD74 moleculeprovided by CGNC
Primary source: CGNC:3398
See related: Ensembl:ENSGALG00010013450
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: II; CD76; ChCD74
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	13	NC_052544.1 (12750532..12754143)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	13	NC_052585.1 (12764273..12767890)

Chromosome 13 - NC_052544.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a novel role of CD74 during IBDV infection, showing that chicken CD74 plays a significant role in IBDV binding to target B cells by interacting with the viral VP2 protein. This is the first report demonstrating that CD74 is involved as a novel attachment receptor in the IBDV life cycle in target B cells, thus contributing new insight into host-pathogen interactions.
Title: Identification of Chicken CD74 as a Novel Cellular Attachment Receptor for Infectious Bursal Disease Virus in Bursa B Lymphocytes.
The cross immunogenicity between Ia-associated invariant chains of chicken and Muscovy duck were located in conserved region.
Title: [Cross immunogenicity between Ia-associated invariant chains of chicken (Gallus domestiaus) and Muscovy duck (Cairina moschata)].
Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor.
Title: Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor.
allele-dependent association of MHC class I molecules with its invariant chain with bases on a multi-site determinative spatial structure
Title: Allele-dependent association of chicken MHC class I molecules with the invariant chain.
cathepsin S is necessary for invariant chain proteolysis in T cells; cathepsin S expression and activity, and concordantly cell surface CLIP expression, was reduced in HLA-DR(+) CD4(+) T cells as compared with B cells
Title: Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells.
Two Leu residues and their ambient amino acid residues are known to exist in the cytosolic tail of chicken invariant chain and play an important role as motifs in mediating the sorting endocytic pathway.
Title: The effect of site-directed mutagenesis of the ambient amino acids of leucine-based sorting motifs on the localization of chicken invariant chain.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables MHC class II protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables macrophage migration inhibitory factor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation involved in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in antigen processing and presentation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of type 2 immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein trimerization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: HLA class II histocompatibility antigen gamma chain

Names: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; MHC class II-associated invariant chain Ii; invariant chain (Ii)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001613.2 → NP_001001613.1 HLA class II histocompatibility antigen gamma chain

See identical proteins and their annotated locations for NP_001001613.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000256

UniProtKB/TrEMBL

A0A1L1RWL6, Q6J613, Q9BD54

Related

ENSGALP00010019150.1, ENSGALT00010032381.1

Conserved Domains (3) summary

cd00191
Location:201 → 259

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam08831
Location:124 → 192

MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain

pfam09307
Location:2 → 110

MHC2-interact; CLIP, MHC2 interacting

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

12750532..12754143

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015293754.4 → XP_015149240.1 HLA class II histocompatibility antigen gamma chain isoform X1

UniProtKB/TrEMBL

Q6J614

Related

ENSGALP00010019170.1, ENSGALT00010032403.1

Conserved Domains (2) summary

pfam08831
Location:124 → 192

MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain

pfam09307
Location:2 → 110

MHC2-interact; CLIP, MHC2 interacting