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CDH5 cadherin 5 [ Bos taurus (domestic cattle) ]

Gene ID: 414735, updated on 30-Jan-2025
Official Symbol
CDH5provided by VGNC
Official Full Name
cadherin 5provided by VGNC
Primary source
VGNC:VGNC:97252
See related
EnsemblRapid:ENSBTAG00070009665
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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See CDH5 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (34122721..34159010)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene uncharacterized LOC104974812 Neighboring gene brain expressed associated with NEDD4 1 Neighboring gene thymidine kinase 2

Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells. Ohashi T, et al. J Biomech, 2007. PMID 17261311
  2. VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function. Iyer S, et al. Am J Physiol Lung Cell Mol Physiol, 2004 Jun. PMID 14672921
  3. VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. Nelson CM, et al. J Cell Sci, 2003 Sep 1. PMID 12876221
  4. Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Gray DS, et al. Exp Cell Res, 2008 Sep 10. PMID 18652824, Free PMC Article
  5. Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Wang Y, et al. Proc Natl Acad Sci U S A, 2006 Feb 7. PMID 16446427, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VE-cadherin induces opposing growth signals.
    Title: VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension.
  2. In all, these results demonstrate that cell-cell contact signals through VE-cadherin, RhoA, and intracellular tension in the actin cytoskeleton to regulate proliferation.
    Title: Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton.
  3. exposure of BAECs to hydrostatic pressure (PHYSIOLOGIC PRESSURE) may downregulate the expression of VE-cadherin, resulting in loss of contact inhibition followed by increased proliferation and formation of a multilayered structure
    Title: Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells.
  4. Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA
    Title: Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA.
  5. results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
    Title: Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras.
  6. investigated the role of catenin p120-VE-cadherin interaction in regulation of barrier function in confluent endothelial monolayers
    Title: VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function.
  7. a VE-cadherin-dependent pathway may link T2-TrpRS to inhibition of new blood vessel formation
    Title: VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell adhesion mediated by cadherin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vasculature development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cadherin-5
Names
VE-cadherin
cadherin 5, type 2 (vascular endothelium)
cadherin 5, type 2, VE-cadherin (vascular endothelium)
cadherin 5, type 2, VE-cadherin (vascular epithelium)
vascular endothelial cadherin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001601.1 → NP_001001601.1  cadherin-5 precursor

    See identical proteins and their annotated locations for NP_001001601.1

    Status: PROVISIONAL

    Source sequence(s)
    AY363224
    UniProtKB/Swiss-Prot
    Q6URK6
    UniProtKB/TrEMBL
    G3MZL1, G5E588
    Related
    ENSBTAP00070012707.1, ENSBTAT00070021702.1
    Conserved Domains (3) summary
    cd11304
    Location:261 → 367
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 147
    CA; Cadherin repeats
    pfam01049
    Location:633 → 774
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34122721..34159010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6URK6.1 GenPept UniProtKB/Swiss-Prot:Q6URK6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials