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CG14740 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41468, updated on 4-Jan-2025

Summary

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Official Symbol
CG14740provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037988
Locus tag
Dmel_CG14740
See related
AllianceGenome:FB:FBgn0037988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.178; CS; Dmel\CG14740
Summary
Predicted to enable citrate (Si)-synthase activity. Predicted to be involved in carbohydrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrial matrix. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG14740 in Genome Data Viewer
Location:
87A6-87A6; 3-51 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12061070..12062944, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7886792..7888666, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ATPase 8B Neighboring gene defective proboscis extension response 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster]. Berezovs'kyĭ VIa, et al. Fiziol Zh (1994), 2014. PMID 25335240
  2. A Colorimetric Assay of Citrate Synthase Activity in Drosophila Melanogaster. Wei P, et al. J Vis Exp, 2020 Jan 16. PMID 32009637
  3. Review: Hypoxic and oxidative stress resistance in Drosophila melanogaster. Zhao HW, et al. Placenta, 2011 Mar. PMID 21353099, Free PMC Article
  4. Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: relevance to neuropathy. Prasad SN, et al. J Insect Physiol, 2014 Jan. PMID 24231732
  5. Genetic link between heme oxygenase and the signaling pathway of DNA damage in Drosophila melanogaster. Ida H, et al. Tohoku J Exp Med, 2013 Oct. PMID 24126234

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes.
    Title: [The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster].
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
  
enables citrate (Si)-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14740-PA
citrate synthase
NP_650152.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12061070..12062944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141895.3 → NP_650152.1  uncharacterized protein Dmel_CG14740 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650152.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TZ4, Q9VGD5
    Related
    FBpp0082025
    Conserved Domains (2) summary
    cd06103
    Location:33 → 458
    ScCS-like; Saccharomyces cerevisiae (Sc) citrate synthase (CS)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). Some CS ...
    COG0372
    Location:67 → 454
    GltA; Citrate synthase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TZ4 Q95TZ4

Gene LinkOut

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