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MATK megakaryocyte-associated tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 4145, updated on 6-Jan-2019

Summary

Official Symbol
MATKprovided by HGNC
Official Full Name
megakaryocyte-associated tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:6906
See related
Ensembl:ENSG00000007264 MIM:600038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHK; CTK; HYL; Lsk; HYLTK; HHYLTK
Summary
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 4.5), bone marrow (RPKM 3.5) and 19 other tissues See more
Orthologs

Genomic context

See MATK in Genome Data Viewer
Location:
19p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (3777969..3801812, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3777967..3801810, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene retina and anterior neural fold homeobox 2 Neighboring gene zinc finger RNA binding protein 2 Neighboring gene ferritin light chain pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

  • Downregulation of ERBB2 signaling, organism-specific biosystem (from REACTOME)
    Downregulation of ERBB2 signaling, organism-specific biosystemSignaling by ERBB2 can be downregulated by ubiquitination and subsequent proteasome-dependent degradation of ERBB2 or activated ERBB2 heterodimers. In addition, protein tyrosine phosphatases that dep...
  • Kit receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Kit receptor signaling pathway, organism-specific biosystemKit is a cytokine receptor that belongs to the type III receptor tyrosine kinase family. It is structurally similar to platelet-derived growth factor recpetors (PDGFRs), colony stimulating factor-1 r...
  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
    Signaling events mediated by Stem cell factor receptor (c-Kit)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1708, MGC2101, DKFZp434N1212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
mesoderm development TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
megakaryocyte-associated tyrosine-protein kinase
Names
CSK homologous kinase
Csk-homologous kinase
Csk-type protein tyrosine kinase
HYL tyrosine kinase
hematopoietic consensus tyrosine-lacking kinase
hydroxyaryl-protein kinase
leukocyte carboxyl-terminal src kinase related
protein kinase HYL
tyrosine kinase MATK
tyrosine-protein kinase CTK
tyrosylprotein kinase
NP_002369.2
NP_647611.1
NP_647612.1
XP_011526320.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002378.3NP_002369.2  megakaryocyte-associated tyrosine-protein kinase isoform b

    See identical proteins and their annotated locations for NP_002369.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate region at the 5' end of the coding region and lacks two exons in the coding region, as compared to variant 1. The encoded isoform b has a slightly longer and unique N-terminus compared to isoform a.
    Source sequence(s)
    AK055395, BC000114, DA592994, X77278
    Consensus CDS
    CCDS12113.1
    UniProtKB/Swiss-Prot
    P42679
    Related
    ENSP00000378485.1, ENST00000395045.6
    Conserved Domains (4) summary
    cd09937
    Location:119216
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11811
    Location:51109
    SH3_CHK; Src Homology 3 domain of CSK homologous kinase
    smart00221
    Location:236479
    STYKc; Protein kinase; unclassified specificity
    cd05083
    Location:229482
    PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase
  2. NM_139354.2NP_647611.1  megakaryocyte-associated tyrosine-protein kinase isoform c

    See identical proteins and their annotated locations for NP_647611.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, and utilizes a downstream in-frame start codon, compared to variant 1. Isoform c has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL137754, BG396388, BQ109562, X77278
    Consensus CDS
    CCDS42468.1
    UniProtKB/Swiss-Prot
    P42679
    Related
    ENSP00000378481.1, ENST00000395040.6
    Conserved Domains (3) summary
    cd09937
    Location:77174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11811
    Location:967
    SH3_CHK; Src Homology 3 domain of CSK homologous kinase
    cd05083
    Location:187440
    PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase
  3. NM_139355.3NP_647612.1  megakaryocyte-associated tyrosine-protein kinase isoform a

    See identical proteins and their annotated locations for NP_647612.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform a.
    Source sequence(s)
    BC000114, BG396388, BM925586
    Consensus CDS
    CCDS12114.1
    UniProtKB/Swiss-Prot
    P42679
    UniProtKB/TrEMBL
    F1T0G6
    Related
    ENSP00000308734.5, ENST00000310132.10
    Conserved Domains (3) summary
    cd09937
    Location:118215
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11811
    Location:50108
    SH3_CHK; Src Homology 3 domain of CSK homologous kinase
    cd05083
    Location:228481
    PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    3777969..3801812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528018.1XP_011526320.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011526320.1

    UniProtKB/Swiss-Prot
    P42679
    UniProtKB/TrEMBL
    F1T0G6
    Conserved Domains (3) summary
    cd09937
    Location:118215
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11811
    Location:50108
    SH3_CHK; Src Homology 3 domain of CSK homologous kinase
    cd05083
    Location:228481
    PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase
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