SDHB succinate dehydrogenase complex iron sulfur subunit B [Sus scrofa (pig)] - Gene

Summary

Official Symbol: SDHBprovided by VGNC
Official Full Name: succinate dehydrogenase complex iron sulfur subunit Bprovided by VGNC
Primary source: VGNC:VGNC:92659
See related: Ensembl:ENSSSCG00000020926 RGD:14076668
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: Ip
Expression: Ubiquitous expression in heart (RPKM 274.5), psoas major muscle (RPKM 256.8) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2026_06	current	Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1)	6	NC_139388.1 (80173996..80204046, complement)
106	previous assembly	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (75648362..75678111, complement)

Chromosome 6 - NC_139388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The gene sequences of each complex II subunit were measured by RT-PCR. N-terminal sequencing work was performed to identify the mitochondrial targeting signal peptide of each subunit.
Title: Preliminary molecular characterization and crystallization of mitochondrial respiratory complex II from porcine heart.
tissue expression analysis indicated that that swine SDHB, SNRPA and CRYBB1 gene were differentially expressed in tissues including fat, lung, muscle, small intestine, kidney, large intestine, spleen and liver
Title: Molecular cloning, sequence identification, and tissue expression profile analysis of three novel porcine genes: SDHB, SNRPA and CRYBB1.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info	PubMed
enables electron transfer activity	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in aerobic respiration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Names: Iron-sulfur subunit of complex II; malate dehydrogenase [quinone] iron-sulfur subunit; succinate dehydrogenase ubiquinone iron-sulfur subunit, mitochondrial

NP_001098423.1

EC 1.3.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001104953.1 → NP_001098423.1 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

See identical proteins and their annotated locations for NP_001098423.1

Status: PROVISIONAL

Source sequence(s)

DQ915498

UniProtKB/Swiss-Prot

Q007T0, Q0QEX6

UniProtKB/TrEMBL

A0A4X1W8G3, I3LDC1

Related

ENSSSCP00000022052.1, ENSSSCT00000027692.3

Conserved Domains (1) summary

PLN00129
Location:29 → 271

PLN00129; succinate dehydrogenase [ubiquinone] iron-sulfur subunit

RefSeqs of Annotated Genomes: GCF_054392235.1-RS_2026_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Genomic

NC_139388.1 Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Range

80173996..80204046 complement

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GenBank, FASTA, Sequence Viewer (Graphics)