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MAT2A methionine adenosyltransferase 2A [ Homo sapiens (human) ]

Gene ID: 4144, updated on 3-Nov-2019

Summary

Official Symbol
MAT2Aprovided by HGNC
Official Full Name
methionine adenosyltransferase 2Aprovided by HGNC
Primary source
HGNC:HGNC:6904
See related
Ensembl:ENSG00000168906 MIM:601468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MATA2; MATII; SAMS2
Summary
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in thyroid (RPKM 234.0), adrenal (RPKM 141.3) and 25 other tissues See more
Orthologs

Genomic context

See MAT2A in Genome Data Viewer
Location:
2p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85539168..85545281)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85766101..85772403)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 22 Neighboring gene promoter of MAT2A antisense radiation-induced circulating long non-coding RNA Neighboring gene gamma-glutamyl carboxylase Neighboring gene RNA, 7SL, cytoplasmic 126, pseudogene Neighboring gene vesicle associated membrane protein 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of methionine adenosyltransferase II, alpha (MAT2A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methionine adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methionine adenosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
S-adenosylmethionine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
methylation TAS
Traceable Author Statement
more info
 
one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein hexamerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
methionine adenosyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methionine adenosyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
S-adenosylmethionine synthase isoform type-2
Names
MAT 2
MAT-II
adoMet synthase 2
adoMet synthetase 2
methionine adenosyltransferase 2
methionine adenosyltransferase II, alpha
testicular tissue protein Li 121
NP_005902.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029183.1 RefSeqGene

    Range
    5191..11304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005911.6NP_005902.1  S-adenosylmethionine synthase isoform type-2

    See identical proteins and their annotated locations for NP_005902.1

    Status: REVIEWED

    Source sequence(s)
    AC016753, BC001686, DC322518
    Consensus CDS
    CCDS1977.1
    UniProtKB/Swiss-Prot
    P31153
    UniProtKB/TrEMBL
    A0A140VJP5
    Related
    ENSP00000303147.3, ENST00000306434.8
    Conserved Domains (1) summary
    PTZ00104
    Location:16395
    PTZ00104; S-adenosylmethionine synthase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    85539168..85545281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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