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IDNK IDNK gluconokinase [ Homo sapiens (human) ]

Gene ID: 414328, updated on 21-Dec-2019

Summary

Official Symbol
IDNKprovided by HGNC
Official Full Name
IDNK gluconokinaseprovided by HGNC
Primary source
HGNC:HGNC:31367
See related
Ensembl:ENSG00000148057 MIM:611343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hGntK; C9orf103; bA522I20.2
Expression
Ubiquitous expression in kidney (RPKM 3.7), liver (RPKM 2.2) and 25 other tissues See more
Orthologs

Genomic context

See IDNK in Genome Data Viewer
Location:
9q21.32
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (83622324..83644130)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (86237964..86259045)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene FERM domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 2550 Neighboring gene RNA, U4 small nuclear 15, pseudogene Neighboring gene uncharacterized LOC105376114 Neighboring gene ubiquilin 1 Neighboring gene G kinase anchoring protein 1 Neighboring gene uncharacterized LOC101927552

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
gluconokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
D-gluconate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
D-gluconate catabolic process IEA
Inferred from Electronic Annotation
more info
 
biological_process ND
No biological Data available
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable gluconokinase
Names
glucokinase-like protein
gluconate kinase
gluconokinase-like protein
idnK, gluconokinase homolog
NP_001001551.2
NP_001243844.1
NP_001338464.1
XP_006717173.1
XP_006717174.1
XP_016870208.1
XP_016870209.1
XP_016870210.1
XP_016870211.1
XP_016870213.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001551.4NP_001001551.2  probable gluconokinase isoform 1

    See identical proteins and their annotated locations for NP_001001551.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AY615889, BC036421
    Consensus CDS
    CCDS35048.2
    UniProtKB/Swiss-Prot
    Q5T6J7
    Related
    ENSP00000365601.4, ENST00000376419.5
    Conserved Domains (2) summary
    COG3265
    Location:10185
    GntK; Gluconate kinase [Carbohydrate transport and metabolism]
    pfam13671
    Location:7158
    AAA_33; AAA domain
  2. NM_001256915.1NP_001243844.1  probable gluconokinase isoform 3

    See identical proteins and their annotated locations for NP_001243844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1. Variants 3 and 5 encode the same isoform (3).
    Source sequence(s)
    AY615889, BC036421, CB151823, W69675
    Consensus CDS
    CCDS59134.1
    UniProtKB/Swiss-Prot
    Q5T6J7
    UniProtKB/TrEMBL
    A0A024R247
    Related
    ENSP00000403290.2, ENST00000454393.5
    Conserved Domains (1) summary
    cl17190
    Location:1139
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  3. NM_001351535.2NP_001338464.1  probable gluconokinase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1. Variants 3 and 5 encode the same isoform (3).
    Source sequence(s)
    AY615889, BC036421, CB151823
    Consensus CDS
    CCDS59134.1
    Conserved Domains (1) summary
    cl17190
    Location:1139
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RNA

  1. NR_046421.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the predicted ORF is mostly in a different reading frame and it lacks sufficient support for protein representation.
    Source sequence(s)
    BC036421, CA866332
  2. NR_046422.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an additional exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL354920, AY615889, BC036421
    Related
    ENST00000533522.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    83622324..83644130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014722.1XP_016870211.1  probable gluconokinase isoform X5

  2. XM_017014721.1XP_016870210.1  probable gluconokinase isoform X4

  3. XM_006717111.4XP_006717174.1  probable gluconokinase isoform X6

    Conserved Domains (1) summary
    COG3265
    Location:18186
    GntK; Gluconate kinase [Carbohydrate transport and metabolism]
  4. XM_017014720.1XP_016870209.1  probable gluconokinase isoform X3

  5. XM_017014719.1XP_016870208.1  probable gluconokinase isoform X1

  6. XM_006717110.3XP_006717173.1  probable gluconokinase isoform X2

    See identical proteins and their annotated locations for XP_006717173.1

    UniProtKB/Swiss-Prot
    Q5T6J7
    Conserved Domains (1) summary
    COG3265
    Location:60228
    GntK; Gluconate kinase [Carbohydrate transport and metabolism]
  7. XM_017014724.1XP_016870213.1  probable gluconokinase isoform X7

    UniProtKB/Swiss-Prot
    Q5T6J7
    UniProtKB/TrEMBL
    A0A024R247
    Conserved Domains (1) summary
    cl17190
    Location:1139
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001190727.1: Suppressed sequence

    Description
    NM_001190727.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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