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HisCl1 Histamine-gated chloride channel subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41426, updated on 6-Jul-2026
Official Symbol
HisCl1provided by FlyBase
Official Full Name
Histamine-gated chloride channel subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0037950
Locus tag
Dmel_CG14723
See related
AllianceGenome:FB:FBgn0037950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14723; CT34515; Dm-HCLB; Dmel\CG14723; DmHisCl1; DMHisClalpha2; HA-CI II; hclB; HisCl; HisCl-alpha2; hiscl1; hisCl1
Summary
Enables histamine-gated chloride channel activity. Involved in chloride transport and thermotaxis. Part of histamine-gated chloride channel complex. Is expressed in several structures, including anterior-posterior subdivision of organism; ganglia; photoreceptor; photoreceptor neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Orthologous to human GLRA1 (glycine receptor alpha 1) and GLRA2 (glycine receptor alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See HisCl1 in Genome Data Viewer
Location:
86F7-86F8; 3-51 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11787176..11789393)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7612898..7615115)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45595 Neighboring gene pruning defect 1 Neighboring gene SET domain binding factor Neighboring gene Chloride channel-a Neighboring gene glorund Neighboring gene Cytochrome c oxidase subunit 5A

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels. Pokala N, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550306, Free PMC Article
  2. Altered ivermectin pharmacology and defective visual system in Drosophila mutants for histamine receptor HCLB. Yusein S, et al. Invert Neurosci, 2008 Dec. PMID 18839229
  3. Functional consequences of mutations in the Drosophila histamine receptor HCLB. Yusein S, et al. J Insect Physiol, 2010 Jan. PMID 19716373, Free PMC Article
  4. Participation of the histamine receptor encoded by the gene hclB (HCLB) in visual sensitivity control: an electroretinographic study in Drosophila melanogaster. Kupenova P, et al. Mol Vis, 2012. PMID 23077407, Free PMC Article
  5. Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel. Iovchev M, et al. J Neurogenet, 2002 Oct-Dec. PMID 12745634

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study results show that both Ort and HisCl1 define two different pathways for circadian entrainment. Whereas Ort contributes through its expression in the interneurons of the optic lobe, HisCl1 mostly contributes through its expression in the Rh6-expressing retinal photoreceptors. The work thus reveals that Rh6-expressing neurons contribute to light-mediated entrainment as both photoreceptors and interneurons.
    Title: The HisCl1 histamine receptor acts in photoreceptors to synchronize Drosophila behavioral rhythms with light-dark cycles.
  2. The activity of HisCl1-expressing neurons is acutely and reversibly silenced by exogenous histamine.
    Title: Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels.
  3. may play an essential and conserved role in insect neurophysiology
    Title: Functional consequences of mutations in the Drosophila histamine receptor HCLB.
  4. These results identify HCLB as an important in vivo target for ivermectin in Drosophila melanogaster, and demonstrate the involvement of this protein in the visual pathway.
    Title: Altered ivermectin pharmacology and defective visual system in Drosophila mutants for histamine receptor HCLB.
  5. Histamine-gated chloride channel hclB signaling via the lamina glia plays a previously unrecognized role in shaping the photoreceptor postsynaptic response on large monopolar cells.
    Title: Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse.
  6. the genes encoding for proteins involved in histamine signaling [histidine decarboxylase (hdc), histamine-gated chloride channel subunit 1 (hisCl1), ora transientless (ort)] cause abnormal temperature preferences
    Title: Histamine and its receptors modulate temperature-preference behaviors in Drosophila.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables histamine-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligand-gated monoatomic anion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in thermotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of histamine-gated chloride channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Histamine-gated chloride channel subunit 1
Names
CG14723-PA
CG14723-PB
CG14723-PC
CG14723-PD
HisCl1-PA
HisCl1-PB
HisCl1-PC
HisCl1-PD
glycine receptor alpha3 subunit-like
histamine-gated chloride channel subunit 1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11787176..11789393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169429.4 → NP_731632.1  Histamine-gated chloride channel subunit 1, isoform A

    See identical proteins and their annotated locations for NP_731632.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KFE6, Q8T9R9, Q9VGI0
    Related
    FBpp0081946
    Conserved Domains (2) summary
    pfam02931
    Location:67 → 262
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:270 → 350
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_141859.4 → NP_650116.2  Histamine-gated chloride channel subunit 1, isoform B

    See identical proteins and their annotated locations for NP_650116.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5SUY9, Q7KSP1, Q8WS32
    Conserved Domains (2) summary
    pfam02931
    Location:67 → 262
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:270 → 350
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  3. NM_001170120.2 → NP_001163591.1  Histamine-gated chloride channel subunit 1, isoform D

    See identical proteins and their annotated locations for NP_001163591.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5SUY9, E1JII9
    Conserved Domains (2) summary
    pfam02931
    Location:67 → 256
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:264 → 344
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  4. NM_206474.3 → NP_996196.1  Histamine-gated chloride channel subunit 1, isoform C

    See identical proteins and their annotated locations for NP_996196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSP0, Q95T69
    Conserved Domains (1) summary
    pfam02931
    Location:67 → 202
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JII9 E1JII9
Q8T9R9 Q8T9R9
Q8WS32 Q8WS32
Q95T69 Q95T69
Q9VGI0 Q9VGI0

Gene LinkOut

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