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MAS1 MAS1 proto-oncogene, G protein-coupled receptor [ Homo sapiens (human) ]

Gene ID: 4142, updated on 12-Aug-2022

Summary

Official Symbol
MAS1provided by HGNC
Official Full Name
MAS1 proto-oncogene, G protein-coupled receptorprovided by HGNC
Primary source
HGNC:HGNC:6899
See related
Ensembl:ENSG00000130368 MIM:165180; AllianceGenome:HGNC:6899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAS; MGRA
Summary
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
Orthologs
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Genomic context

See MAS1 in Genome Data Viewer
Location:
6q25.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (159888787..159917447)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (161136662..161163224)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160312020..160338479)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene PARN like ribonuclease domain containing exonuclease 1 Neighboring gene Sharpr-MPRA regulatory region 15614 Neighboring gene Sharpr-MPRA regulatory region 12427 Neighboring gene insulin like growth factor 2 receptor

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119966

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables angiotensin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables angiotensin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables angiotensin type II receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables peptide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of NF-kappaB-inducing kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to gonadotropin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proto-oncogene Mas
Names
MAS1 oncogene
Mas-related G protein-coupled receptor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366704.2NP_001353633.1  proto-oncogene Mas

    Status: REVIEWED

    Source sequence(s)
    AL035691
    UniProtKB/Swiss-Prot
    Q6FG47
    UniProtKB/TrEMBL
    W8W3P4
    Related
    ENSP00000252660.4, ENST00000252660.5
    Conserved Domains (1) summary
    cd15110
    Location:33307
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_002377.4NP_002368.1  proto-oncogene Mas

    See identical proteins and their annotated locations for NP_002368.1

    Status: REVIEWED

    Source sequence(s)
    AL035691, DB475311
    Consensus CDS
    CCDS5272.1
    UniProtKB/Swiss-Prot
    P04201, Q6FG47
    UniProtKB/TrEMBL
    W8W3P4
    Related
    ENSP00000501180.2, ENST00000674077.2
    Conserved Domains (1) summary
    cd15110
    Location:33307
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    159888787..159917447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418776.1XP_047274732.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    Q6FG47
    UniProtKB/TrEMBL
    W8W3P4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    161136662..161163224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)