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TBC1D3C TBC1 domain family member 3C [ Homo sapiens (human) ]

Gene ID: 414060, updated on 24-Nov-2020

Summary

Official Symbol
TBC1D3Cprovided by HGNC
Official Full Name
TBC1 domain family member 3Cprovided by HGNC
Primary source
HGNC:HGNC:24889
See related
Ensembl:ENSG00000278299 MIM:610806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRC17; TBC1D3; TBC1D3A; TBC1D3D
Summary
This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014]
Expression
Broad expression in testis (RPKM 17.2), skin (RPKM 10.9) and 24 other tissues See more

Genomic context

See TBC1D3C in Genome Data Viewer
Location:
17q12
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (38057693..38068634, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34581085..34592039, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 3D Neighboring gene uncharacterized LOC102723819 Neighboring gene puromycin-sensitive aminopeptidase-like protein Neighboring gene TBC1 domain family member 3E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ78248, FLJ93850, MGC44903, MGC87893, DKFZp434P2235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TBC1 domain family member 3C
Names
Prostate cancer gene 17 protein
Protein TRE17-alpha
Rab GTPase-activating protein PRC17
TBC1 domain family member 3
TBC1 domain family member 3C-like protein ENSP00000341742
TBC1 domain family member 3C/3D

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001418.6NP_001001418.5  TBC1 domain family member 3C

    See identical proteins and their annotated locations for NP_001001418.5

    Status: REVIEWED

    Source sequence(s)
    AC233968
    Consensus CDS
    CCDS74045.1
    UniProtKB/Swiss-Prot
    Q6IPX1, Q8IZP1
    Related
    ENSP00000482345.1, ENST00000622206.1
    Conserved Domains (1) summary
    smart00164
    Location:99312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    38057693..38068634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721905.2XP_006721968.1  TBC1 domain family member 3C isoform X2

    Conserved Domains (1) summary
    smart00164
    Location:160351
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  2. XM_017024646.1XP_016880135.1  TBC1 domain family member 3C isoform X3

    Conserved Domains (1) summary
    smart00164
    Location:160372
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  3. XM_006721904.2XP_006721967.1  TBC1 domain family member 3C isoform X1

    See identical proteins and their annotated locations for XP_006721967.1

    Conserved Domains (1) summary
    smart00164
    Location:160373
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  4. XM_011524814.2XP_011523116.1  TBC1 domain family member 3C isoform X1

    See identical proteins and their annotated locations for XP_011523116.1

    Conserved Domains (1) summary
    smart00164
    Location:160373
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  5. XM_006721907.3XP_006721970.1  TBC1 domain family member 3C isoform X4

    Conserved Domains (1) summary
    smart00164
    Location:99290
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  6. XM_006721908.2XP_006721971.1  TBC1 domain family member 3C isoform X5

    See identical proteins and their annotated locations for XP_006721971.1

    Conserved Domains (1) summary
    smart00164
    Location:160361
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187661.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    207820..218767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_037916385.1XP_037772313.1  TBC1 domain family member 3C isoform X8

  2. XM_037916384.1XP_037772312.1  TBC1 domain family member 3C isoform X7

  3. XM_037916383.1XP_037772311.1  TBC1 domain family member 3C isoform X6

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