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MARK3 microtubule affinity regulating kinase 3 [ Homo sapiens (human) ]

Gene ID: 4140, updated on 9-Jun-2020

Summary

Official Symbol
MARK3provided by HGNC
Official Full Name
microtubule affinity regulating kinase 3provided by HGNC
Primary source
HGNC:HGNC:6897
See related
Ensembl:ENSG00000075413 MIM:602678
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KP78; VIPB; CTAK1; PAR1A; Par-1a
Summary
The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 22.5), testis (RPKM 17.6) and 25 other tissues See more
Orthologs

Genomic context

See MARK3 in Genome Data Viewer
Location:
14q32.32-q32.33
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (103385364..103503831)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103851701..103970168)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene high mobility group box 3 pseudogene 26 Neighboring gene ribosomal protein SA pseudogene 5 Neighboring gene ribosomal protein L10a pseudogene 1 Neighboring gene uncharacterized LOC112268130 Neighboring gene creatine kinase B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
VISUAL IMPAIRMENT AND PROGRESSIVE PHTHISIS BULBI
MedGen: C4748978 OMIM: 618283 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tau-protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MAP/microtubule affinity-regulating kinase 3
Names
C-TAK1
ELKL motif kinase 2
EMK-2
cdc25C-associated protein kinase 1
protein kinase STK10
ser/Thr protein kinase PAR-1
serine/threonine-protein kinase p78
NP_001122390.2
NP_001122391.2
NP_001122392.2
NP_001122393.2
NP_002367.5
XP_005267698.2
XP_005267699.2
XP_005267700.2
XP_011535071.1
XP_016876780.1
XP_016876781.1
XP_016876782.1
XP_016876783.1
XP_016876784.1
XP_016876785.1
XP_016876786.1
XP_016876787.1
XP_016876788.1
XP_016876790.1
XP_016876795.1
XP_016876796.1
XP_016876797.1
XP_024305351.1
XP_024305352.1
XP_024305353.1
XP_024305354.1
XP_024305355.1
XP_024305356.1
XP_024305357.1
XP_024305358.1
XP_024305359.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030339.2 RefSeqGene

    Range
    5052..123468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128918.3NP_001122390.2  MAP/microtubule affinity-regulating kinase 3 isoform a

    See identical proteins and their annotated locations for NP_001122390.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF465413, AL133367, BC024773, BX248250, DA707357
    Consensus CDS
    CCDS45165.1
    UniProtKB/Swiss-Prot
    P27448
    UniProtKB/TrEMBL
    A0A0A0MT23, Q86U11
    Related
    ENSP00000411397.2, ENST00000429436.7
    Conserved Domains (3) summary
    cd12196
    Location:654751
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:325367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  2. NM_001128919.2NP_001122391.2  MAP/microtubule affinity-regulating kinase 3 isoform b

    See identical proteins and their annotated locations for NP_001122391.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF387637, AF465413, AL133367, BC024773, BX248250, DA707357
    Consensus CDS
    CCDS45166.1
    UniProtKB/Swiss-Prot
    P27448
    UniProtKB/TrEMBL
    Q86U11
    Related
    ENSP00000450772.1, ENST00000553942.5
    Conserved Domains (4) summary
    cd12196
    Location:645742
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:56307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:325367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  3. NM_001128920.2NP_001122392.2  MAP/microtubule affinity-regulating kinase 3 isoform d

    See identical proteins and their annotated locations for NP_001122392.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL133367, BC024773, DA707357, M80359
    Consensus CDS
    CCDS55947.1
    UniProtKB/Swiss-Prot
    P27448
    UniProtKB/TrEMBL
    A0A0A0MQR8
    Related
    ENSP00000216288.7, ENST00000216288.11
    Conserved Domains (4) summary
    cd12196
    Location:614711
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:56307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:325367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  4. NM_001128921.2NP_001122393.2  MAP/microtubule affinity-regulating kinase 3 isoform e

    See identical proteins and their annotated locations for NP_001122393.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL133367, BC024773, BX161395, DA707357, KF456011
    Consensus CDS
    CCDS45167.1
    UniProtKB/Swiss-Prot
    P27448
    UniProtKB/TrEMBL
    A0A0A0MST9
    Related
    ENSP00000402104.3, ENST00000440884.7
    Conserved Domains (4) summary
    cd12196
    Location:560657
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:56228
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:246288
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:55228
    PKc_like; Protein Kinases, catalytic domain
  5. NM_002376.6NP_002367.5  MAP/microtubule affinity-regulating kinase 3 isoform c

    See identical proteins and their annotated locations for NP_002367.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL133367, BC024773, DA707357
    Consensus CDS
    CCDS41993.1
    UniProtKB/Swiss-Prot
    P27448
    Related
    ENSP00000303698.9, ENST00000303622.13
    Conserved Domains (3) summary
    cd12196
    Location:630727
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:325367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    103385364..103503831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449583.1XP_024305351.1  MAP/microtubule affinity-regulating kinase 3 isoform X1

    Conserved Domains (3) summary
    cd12196
    Location:640737
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:311353
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:41293
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  2. XM_017021306.2XP_016876795.1  MAP/microtubule affinity-regulating kinase 3 isoform X20

  3. XM_024449586.1XP_024305354.1  MAP/microtubule affinity-regulating kinase 3 isoform X17

    Conserved Domains (3) summary
    cd12196
    Location:508605
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:194236
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1176
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017021308.2XP_016876797.1  MAP/microtubule affinity-regulating kinase 3 isoform X21

  5. XM_017021307.2XP_016876796.1  MAP/microtubule affinity-regulating kinase 3 isoform X20

    Related
    ENSP00000450460.1, ENST00000554627.5
  6. XM_017021299.2XP_016876788.1  MAP/microtubule affinity-regulating kinase 3 isoform X13

  7. XM_005267643.5XP_005267700.2  MAP/microtubule affinity-regulating kinase 3 isoform X14

    Conserved Domains (4) summary
    cd12196
    Location:544641
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:56307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:325367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  8. XM_005267642.5XP_005267699.2  MAP/microtubule affinity-regulating kinase 3 isoform X3

    See identical proteins and their annotated locations for XP_005267699.2

    Conserved Domains (4) summary
    cd12196
    Location:638735
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:56307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:325367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  9. XM_017021292.2XP_016876781.1  MAP/microtubule affinity-regulating kinase 3 isoform X5

  10. XM_017021291.2XP_016876780.1  MAP/microtubule affinity-regulating kinase 3 isoform X4

  11. XM_005267641.5XP_005267698.2  MAP/microtubule affinity-regulating kinase 3 isoform X2

    Conserved Domains (4) summary
    cd12196
    Location:639736
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:56307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:325367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  12. XM_024449584.1XP_024305352.1  MAP/microtubule affinity-regulating kinase 3 isoform X15

    Conserved Domains (3) summary
    cd12196
    Location:523620
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:194236
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1176
    PKc_like; Protein Kinases, catalytic domain
  13. XM_024449587.1XP_024305355.1  MAP/microtubule affinity-regulating kinase 3 isoform X18

    Conserved Domains (3) summary
    cd12196
    Location:499596
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:194236
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1176
    PKc_like; Protein Kinases, catalytic domain
  14. XM_017021296.2XP_016876785.1  MAP/microtubule affinity-regulating kinase 3 isoform X9

  15. XM_024449585.1XP_024305353.1  MAP/microtubule affinity-regulating kinase 3 isoform X16

    Conserved Domains (3) summary
    cd12196
    Location:514611
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:194236
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1176
    PKc_like; Protein Kinases, catalytic domain
  16. XM_024449588.1XP_024305356.1  MAP/microtubule affinity-regulating kinase 3 isoform X19

    Conserved Domains (3) summary
    cd12196
    Location:498595
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:194236
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1176
    PKc_like; Protein Kinases, catalytic domain
  17. XM_017021295.2XP_016876784.1  MAP/microtubule affinity-regulating kinase 3 isoform X8

  18. XM_017021298.2XP_016876787.1  MAP/microtubule affinity-regulating kinase 3 isoform X12

  19. XM_017021297.2XP_016876786.1  MAP/microtubule affinity-regulating kinase 3 isoform X11

  20. XM_017021294.2XP_016876783.1  MAP/microtubule affinity-regulating kinase 3 isoform X7

  21. XM_024449590.1XP_024305358.1  MAP/microtubule affinity-regulating kinase 3 isoform X23

    Conserved Domains (3) summary
    cd12196
    Location:473570
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:168210
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:4150
    PKc_like; Protein Kinases, catalytic domain
  22. XM_024449589.1XP_024305357.1  MAP/microtubule affinity-regulating kinase 3 isoform X22

    Conserved Domains (3) summary
    cd12196
    Location:488585
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:168210
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:4150
    PKc_like; Protein Kinases, catalytic domain
  23. XM_017021301.2XP_016876790.1  MAP/microtubule affinity-regulating kinase 3 isoform X15

    Conserved Domains (3) summary
    cd12196
    Location:523620
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:194236
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1176
    PKc_like; Protein Kinases, catalytic domain
  24. XM_024449591.1XP_024305359.1  MAP/microtubule affinity-regulating kinase 3 isoform X23

    Conserved Domains (3) summary
    cd12196
    Location:473570
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:168210
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:4150
    PKc_like; Protein Kinases, catalytic domain
  25. XM_017021293.1XP_016876782.1  MAP/microtubule affinity-regulating kinase 3 isoform X6

  26. XM_011536769.3XP_011535071.1  MAP/microtubule affinity-regulating kinase 3 isoform X10

    Conserved Domains (4) summary
    cd12196
    Location:574671
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    COG0515
    Location:2328
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14407
    Location:245287
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:2227
    PKc_like; Protein Kinases, catalytic domain
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