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MARK1 microtubule affinity regulating kinase 1 [ Homo sapiens (human) ]

Gene ID: 4139, updated on 11-Sep-2019

Summary

Official Symbol
MARK1provided by HGNC
Official Full Name
microtubule affinity regulating kinase 1provided by HGNC
Primary source
HGNC:HGNC:6896
See related
Ensembl:ENSG00000116141 MIM:606511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARK; Par1c; Par-1c
Expression
Broad expression in brain (RPKM 4.9), testis (RPKM 3.5) and 21 other tissues See more
Orthologs

Genomic context

See MARK1 in Genome Data Viewer
Location:
1q41
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (220528136..220664461)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (220701568..220837799)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372928 Neighboring gene long intergenic non-protein coding RNA 2779 Neighboring gene RNA, 7SL, cytoplasmic 464, pseudogene Neighboring gene histone deacetylase 1 pseudogene 2 Neighboring gene chromosome 1 open reading frame 115 Neighboring gene mitochondrial amidoxime reducing component 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
NHGRI GWA Catalog
Genome-wide association study in bipolar patients stratified by co-morbidity.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of MAP/microtubule affinity-regulating kinase 1 (MARK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1477, MGC126512, MGC126513

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tau-protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of mitochondrion localization ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase MARK1
Names
MAP/microtubule affinity-regulating kinase 1
PAR1 homolog c
NP_001273053.1
NP_001273055.1
NP_001273057.1
NP_001273058.1
NP_061120.3
XP_005273191.1
XP_006711389.1
XP_011507863.1
XP_011507864.1
XP_016856794.1
XP_016856795.1
XP_016856796.1
XP_024302858.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286124.1NP_001273053.1  serine/threonine-protein kinase MARK1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK314614, AL592406, BC068608, CA412112
    Consensus CDS
    CCDS73033.1
    UniProtKB/TrEMBL
    A0A087X0I6
    Related
    ENSP00000483424.1, ENST00000611084.4
    Conserved Domains (4) summary
    cd12196
    Location:697794
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:60311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14405
    Location:331371
    UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
    cd14072
    Location:59311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  2. NM_001286126.1NP_001273055.1  serine/threonine-protein kinase MARK1 isoform 3

    See identical proteins and their annotated locations for NP_001273055.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AK295506, AL592406, BC068608, CA412112
    Consensus CDS
    CCDS73034.1
    UniProtKB/TrEMBL
    B4DIB3
    Related
    ENSP00000386017.2, ENST00000402574.5
    Conserved Domains (4) summary
    cd12196
    Location:681778
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:60311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14405
    Location:331371
    UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
    cd14072
    Location:59311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  3. NM_001286128.2NP_001273057.1  serine/threonine-protein kinase MARK1 isoform 4

    See identical proteins and their annotated locations for NP_001273057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AB040910, AC096640, AL592406, BC068608, CA412112
    Consensus CDS
    CCDS65789.1
    UniProtKB/Swiss-Prot
    Q9P0L2
    Related
    ENSP00000355885.4, ENST00000366918.8
    Conserved Domains (4) summary
    cd12196
    Location:659756
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:60289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14405
    Location:309349
    UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
    cl21453
    Location:59289
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001286129.2NP_001273058.1  serine/threonine-protein kinase MARK1 isoform 5

    See identical proteins and their annotated locations for NP_001273058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC096640, BC068608
    Conserved Domains (1) summary
    cl21453
    Location:59105
    PKc_like; Protein Kinases, catalytic domain
  5. NM_018650.5NP_061120.3  serine/threonine-protein kinase MARK1 isoform 2

    See identical proteins and their annotated locations for NP_061120.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC096640, AL592406, BC068608, BC113869, CA412112
    Consensus CDS
    CCDS31029.2
    UniProtKB/Swiss-Prot
    Q9P0L2
    Related
    ENSP00000355884.4, ENST00000366917.5
    Conserved Domains (4) summary
    cd12196
    Location:696793
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:60311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14405
    Location:331371
    UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
    cd14072
    Location:59311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    220528136..220664461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509562.3XP_011507864.1  serine/threonine-protein kinase MARK1 isoform X4

    Conserved Domains (4) summary
    cd12196
    Location:587684
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:1201
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14405
    Location:221261
    UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
    cl21453
    Location:1201
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017001306.2XP_016856795.1  serine/threonine-protein kinase MARK1 isoform X5

  3. XM_005273134.5XP_005273191.1  serine/threonine-protein kinase MARK1 isoform X2

    See identical proteins and their annotated locations for XP_005273191.1

    UniProtKB/TrEMBL
    X5D2M4
    Conserved Domains (4) summary
    cd12196
    Location:682779
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:60311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14405
    Location:331371
    UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
    cd14072
    Location:59311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  4. XM_024447090.1XP_024302858.1  serine/threonine-protein kinase MARK1 isoform X7

    Conserved Domains (1) summary
    cd14072
    Location:59303
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  5. XM_017001307.2XP_016856796.1  serine/threonine-protein kinase MARK1 isoform X6

  6. XM_017001305.2XP_016856794.1  serine/threonine-protein kinase MARK1 isoform X4

    Conserved Domains (4) summary
    cd12196
    Location:587684
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:1201
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14405
    Location:221261
    UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
    cl21453
    Location:1201
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011509561.3XP_011507863.1  serine/threonine-protein kinase MARK1 isoform X1

    Conserved Domains (4) summary
    cd12196
    Location:689786
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:52303
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14405
    Location:323363
    UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
    cd14072
    Location:51303
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  8. XM_006711326.4XP_006711389.1  serine/threonine-protein kinase MARK1 isoform X3

    Conserved Domains (4) summary
    cd12196
    Location:609706
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:15223
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14405
    Location:243283
    UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
    cl21453
    Location:10223
    PKc_like; Protein Kinases, catalytic domain
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