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MAPT microtubule associated protein tau [ Homo sapiens (human) ]

Gene ID: 4137, updated on 8-Jul-2018
Official Symbol
MAPTprovided by HGNC
Official Full Name
microtubule associated protein tauprovided by HGNC
Primary source
HGNC:HGNC:6893
See related
Ensembl:ENSG00000186868 MIM:157140; Vega:OTTHUMG00000168833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
Summary
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 70.2), kidney (RPKM 12.0) and 2 other tissues See more
Orthologs
See MAPT in Genome Data Viewer
Location:
17q21.31
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (45894382..46028334)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43971702..44105700)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene LINC02210-CRHR1 readthrough Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene MAPT antisense RNA 1 Neighboring gene signal peptide peptidase like 2C Neighboring gene uncharacterized LOC105371800 Neighboring gene MAPT intronic transcript 1 Neighboring gene saitohin Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene uncharacterized LOC107985027 Neighboring gene KANSL1 antisense RNA 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-05-08)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-05-08)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
NHGRI GWA Catalog
Common variants at 12q15 and 12q24 are associated with infant head circumference.
NHGRI GWA Catalog
Common variants at 6q22 and 17q21 are associated with intracranial volume.
NHGRI GWA Catalog
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.
NHGRI GWA Catalog
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
NHGRI GWA Catalog
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
NHGRI GWA Catalog
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
NHGRI GWA Catalog
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
NHGRI GWA Catalog
Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
NHGRI GWA Catalog
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
NHGRI GWA Catalog
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
NHGRI GWA Catalog
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat increases cellular amounts of phosphorylated MAPT (Tau); increases are dependent upon Tat amino acids 31-61 and can be inhibited by caffeine PubMed
tat HIV-1 Tat induces hyperphosphorylation of Tau PubMed
tat HIV-1 Tat induces hyperphosphorylation of Tau in neuronal cells PubMed
tat Treatment of microglia cells with HIV-1 Tat shows TAU5 and synapsin-1 positive inclusions in cells PubMed

Go to the HIV-1, Human Interaction Database

  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
    Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
    Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
  • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
    Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
    Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemCaspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and ...
  • Copper homeostasis, organism-specific biosystem (from WikiPathways)
    Copper homeostasis, organism-specific biosystemCopper is a redox-active transition metal and an essential trace element for life. It is a catalytic cofactor for numerous enzymes involved in critical biological processes (eg. detoxyfication by oxy...
  • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
  • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-5 Signaling Pathway, organism-specific biosystemInterleukin 5 (IL-5) ligand belongs to the cytokine superfamily. IL-5 is a glycoprotein which belongs to the cytokine superfamily. It possesses the four helical bundle motifs that is conserved among ...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Kit receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Kit receptor signaling pathway, organism-specific biosystemKit is a cytokine receptor that belongs to the type III receptor tyrosine kinase family. It is structurally similar to platelet-derived growth factor recpetors (PDGFRs), colony stimulating factor-1 r...
  • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
    LPA receptor mediated events, organism-specific biosystem
    LPA receptor mediated events
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Notch Signaling Pathway, organism-specific biosystemThe Notch pathway is an evolutionally conserved signaling pathway which plays an important role in diverse developmental and physiological processes. These include cell-fate determination, tissue pat...
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
  • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Reelin signaling pathway, organism-specific biosystem
    Reelin signaling pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ31424, MGC138549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AT DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin binding TAS
Traceable Author Statement
more info
PubMed 
apolipoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
double-stranded DNA binding TAS
Traceable Author Statement
more info
PubMed 
dynactin binding TAS
Traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
histone-dependent DNA binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein particle binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule binding NAS
Non-traceable Author Statement
more info
PubMed 
microtubule binding TAS
Traceable Author Statement
more info
PubMed 
microtubule lateral binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol binding TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol bisphosphate binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging TAS
Traceable Author Statement
more info
PubMed 
protein homodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphatase 2A binding TAS
Traceable Author Statement
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding TAS
Traceable Author Statement
more info
PubMed 
single-stranded DNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
astrocyte activation TAS
Traceable Author Statement
more info
PubMed 
axon development TAS
Traceable Author Statement
more info
PubMed 
axonal transport NAS
Non-traceable Author Statement
more info
PubMed 
axonal transport TAS
Traceable Author Statement
more info
PubMed 
axonal transport of mitochondrion TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to brain-derived neurotrophic factor stimulus TAS
Traceable Author Statement
more info
PubMed 
cellular response to heat TAS
Traceable Author Statement
more info
PubMed 
cellular response to nerve growth factor stimulus TAS
Traceable Author Statement
more info
PubMed 
cellular response to reactive oxygen species TAS
Traceable Author Statement
more info
PubMed 
central nervous system neuron development TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic microtubule organization TAS
Traceable Author Statement
more info
PubMed 
generation of neurons NAS
Non-traceable Author Statement
more info
PubMed 
internal protein amino acid acetylation TAS
Traceable Author Statement
more info
PubMed 
intracellular distribution of mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
microglial cell activation TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
microtubule polymerization TAS
Traceable Author Statement
more info
PubMed 
negative regulation of establishment of protein localization to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tubulin deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of tubulin deacetylation TAS
Traceable Author Statement
more info
PubMed 
neurofibrillary tangle assembly NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection development TAS
Traceable Author Statement
more info
PubMed 
plus-end-directed organelle transport along microtubule TAS
Traceable Author Statement
more info
PubMed 
positive regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of diacylglycerol kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein complex oligomerization TAS
Traceable Author Statement
more info
PubMed 
rRNA metabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of chromosome organization TAS
Traceable Author Statement
more info
PubMed 
regulation of long term synaptic depression TAS
Traceable Author Statement
more info
PubMed 
regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of microtubule polymerization NAS
Non-traceable Author Statement
more info
PubMed 
regulation of microtubule polymerization TAS
Traceable Author Statement
more info
PubMed 
regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrial fission IC
Inferred by Curator
more info
PubMed 
regulation of response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
response to lead ion ISS
Inferred from Sequence or Structural Similarity
more info
 
stress granule assembly TAS
Traceable Author Statement
more info
PubMed 
supramolecular fiber organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axolemma IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon NAS
Non-traceable Author Statement
more info
PubMed 
axon TAS
Traceable Author Statement
more info
PubMed 
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine TAS
Traceable Author Statement
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
glial cell projection ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
intracellular NAS
Non-traceable Author Statement
more info
PubMed 
intracellular TAS
Traceable Author Statement
more info
PubMed 
main axon ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
neurofibrillary tangle IDA
Inferred from Direct Assay
more info
PubMed 
neurofibrillary tangle NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
somatodendritic compartment IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatodendritic compartment TAS
Traceable Author Statement
more info
PubMed 
tubulin complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
microtubule-associated protein tau
Names
G protein beta1/gamma2 subunit-interacting factor 1
PHF-tau
microtubule-associated protein tau, isoform 4
neurofibrillary tangle protein
paired helical filament-tau
protein phosphatase 1, regulatory subunit 103

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007398.1 RefSeqGene

    Range
    4921..138924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001123066.3NP_001116538.2  microtubule-associated protein tau isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (6).
    Source sequence(s)
    AW295014, BN000503, CR936218, DN996935
    Consensus CDS
    CCDS45715.1
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000340820.5, ENST00000344290.9
    Conserved Domains (1) summary
    pfam00418
    Location:610639
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. NM_001123067.3NP_001116539.1  microtubule-associated protein tau isoform 5

    See identical proteins and their annotated locations for NP_001116539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (5) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
    Source sequence(s)
    BC114948, CR936218, DN996935
    Consensus CDS
    CCDS45716.1
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000340438.5, ENST00000340799.9
    Conserved Domains (2) summary
    pfam00418
    Location:246275
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl28033
    Location:27233
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  3. NM_001203251.1NP_001190180.1  microtubule-associated protein tau isoform 7

    See identical proteins and their annotated locations for NP_001190180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (7) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
    Source sequence(s)
    AK095802, CR936218, DN996935
    UniProtKB/TrEMBL
    A0A024RA19, B3KTM0
    Conserved Domains (1) summary
    pfam00418
    Location:246275
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. NM_001203252.1NP_001190181.1  microtubule-associated protein tau isoform 8

    See identical proteins and their annotated locations for NP_001190181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (8) has identical N- and C-termini but lacks three segments, as compared to isoform 6.
    Source sequence(s)
    AK095802, BN000503, CR936218, DN996935
    Consensus CDS
    CCDS56033.1
    UniProtKB/Swiss-Prot
    P10636
    UniProtKB/TrEMBL
    B3KTM0
    Related
    ENSP00000443028.1, ENST00000535772.5
    Conserved Domains (1) summary
    pfam00418
    Location:275304
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. NM_005910.5NP_005901.2  microtubule-associated protein tau isoform 2

    See identical proteins and their annotated locations for NP_005901.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (2) has identical N- and C-termini but lacks three segments, as compared to isoform 6.
    Source sequence(s)
    BN000503, CR936218, DN996935, X14474
    Consensus CDS
    CCDS11499.1
    UniProtKB/Swiss-Prot
    P10636
    UniProtKB/TrEMBL
    A0A024RA17
    Related
    ENSP00000303214.7, ENST00000351559.9
    Conserved Domains (1) summary
    pfam00418
    Location:275304
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. NM_016834.4NP_058518.1  microtubule-associated protein tau isoform 3

    See identical proteins and their annotated locations for NP_058518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks five internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (3) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
    Source sequence(s)
    BC114948, CR936218, DN996935
    Consensus CDS
    CCDS11500.1
    UniProtKB/Swiss-Prot
    P10636
    UniProtKB/TrEMBL
    A0A024R9Y0
    Related
    ENSP00000408975.3, OTTHUMP00000239569, ENST00000446361.7, OTTHUMT00000401263
    Conserved Domains (1) summary
    pfam00418
    Location:217246
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  7. NM_016835.4NP_058519.3  microtubule-associated protein tau isoform 1

    See identical proteins and their annotated locations for NP_058519.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks one internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (1) has identical N- and C-termini but lacks one segment, as compared to isoform 6.
    Source sequence(s)
    AW295014, BC114948, BN000503, CR936218, DN996935
    Consensus CDS
    CCDS11501.1
    UniProtKB/Swiss-Prot
    P10636
    UniProtKB/TrEMBL
    A0A024R9Y1
    Related
    ENSP00000262410.5, ENST00000262410.9
    Conserved Domains (1) summary
    pfam00418
    Location:592621
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. NM_016841.4NP_058525.1  microtubule-associated protein tau isoform 4

    See identical proteins and their annotated locations for NP_058525.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks six internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (4) has identical N- and C-termini but lacks five segments, as compared to isoform 6.
    Source sequence(s)
    BC000558, CR936218, DN996935
    Consensus CDS
    CCDS11502.1
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000334886.8, OTTHUMP00000239568, ENST00000334239.12, OTTHUMT00000401262
    Conserved Domains (1) summary
    pfam00418
    Location:217246
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    45894382..46028334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257370.4XP_005257427.1  microtubule-associated protein tau isoform X8

    Conserved Domains (1) summary
    pfam00418
    Location:312341
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. XM_005257366.3XP_005257423.1  microtubule-associated protein tau isoform X4

    Conserved Domains (1) summary
    pfam00418
    Location:638667
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  3. XM_005257362.4XP_005257419.1  microtubule-associated protein tau isoform X1

    Conserved Domains (1) summary
    pfam00418
    Location:696725
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. XM_005257365.4XP_005257422.1  microtubule-associated protein tau isoform X3

    Conserved Domains (1) summary
    pfam00418
    Location:696725
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. XM_005257367.4XP_005257424.1  microtubule-associated protein tau isoform X5

    Conserved Domains (1) summary
    pfam00418
    Location:630659
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. XM_005257368.4XP_005257425.1  microtubule-associated protein tau isoform X6

    Conserved Domains (1) summary
    pfam00418
    Location:630659
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  7. XM_005257369.4XP_005257426.1  microtubule-associated protein tau isoform X7

    Conserved Domains (1) summary
    pfam00418
    Location:341370
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. XM_005257364.4XP_005257421.1  microtubule-associated protein tau isoform X2

    Conserved Domains (1) summary
    pfam00418
    Location:667696
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  9. XM_005257371.4XP_005257428.1  microtubule-associated protein tau isoform X9

    Conserved Domains (1) summary
    pfam00418
    Location:283312
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    760287..893837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    596513..730446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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