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MAP4 microtubule associated protein 4 [ Homo sapiens (human) ]

Gene ID: 4134, updated on 24-Nov-2020

Summary

Official Symbol
MAP4provided by HGNC
Official Full Name
microtubule associated protein 4provided by HGNC
Primary source
HGNC:HGNC:6862
See related
Ensembl:ENSG00000047849 MIM:157132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in heart (RPKM 53.7), brain (RPKM 28.3) and 23 other tissues See more
Orthologs

Genomic context

See MAP4 in Genome Data Viewer
Location:
3p21.31
Exon count:
29
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (47850695..48089272, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47892180..48130769, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 Neighboring gene Sharpr-MPRA regulatory region 56 Neighboring gene DExH-box helicase 30 Neighboring gene microRNA 1226 Neighboring gene VPS26B pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 664, pseudogene Neighboring gene ribosomal protein L17 pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of microtubule-associated protein 4 (MAP4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of DNAL1 and MAP4 by siRNAs and shRNAs inhibits HIV-1 replication in HeLa P4.2 cells by blocking reverse transcription and 2-LTR formation PubMed
Knockdown of microtubule-associated protein 4 (MAP4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated microtubule-associated protein 4 (MAP4) is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with microtubule-associated protein 4 (MAP4) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8617, DKFZp779A1753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of spindle orientation IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule sliding IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
axoneme IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated protein 4
Names
MAP-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052840.1 RefSeqGene

    Range
    5432..243585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134364.2NP_001127836.1  microtubule-associated protein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA904866, AB209377, DA114613
    Consensus CDS
    CCDS46818.1
    UniProtKB/Swiss-Prot
    P27816
    Related
    ENSP00000379083.3, ENST00000395734.7
    Conserved Domains (1) summary
    pfam00418
    Location:9921021
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. NM_001384675.1NP_001371604.1  microtubule-associated protein 4 isoform 92

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  3. NM_001384676.1NP_001371605.1  microtubule-associated protein 4 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  4. NM_001384677.1NP_001371606.1  microtubule-associated protein 4 isoform 74

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  5. NM_001384678.1NP_001371607.1  microtubule-associated protein 4 isoform 55

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  6. NM_001384679.1NP_001371608.1  microtubule-associated protein 4 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  7. NM_001384680.1NP_001371609.1  microtubule-associated protein 4 isoform 86

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  8. NM_001384681.1NP_001371610.1  microtubule-associated protein 4 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  9. NM_001384707.1NP_001371636.1  microtubule-associated protein 4 isoform 62

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  10. NM_001384729.1NP_001371658.1  microtubule-associated protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  11. NM_001384730.1NP_001371659.1  microtubule-associated protein 4 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  12. NM_001384731.1NP_001371660.1  microtubule-associated protein 4 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  13. NM_001384733.1NP_001371662.1  microtubule-associated protein 4 isoform 81

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  14. NM_001384734.1NP_001371663.1  microtubule-associated protein 4 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  15. NM_001384735.1NP_001371664.1  microtubule-associated protein 4 isoform 63

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  16. NM_001384736.1NP_001371665.1  microtubule-associated protein 4 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  17. NM_001384737.1NP_001371666.1  microtubule-associated protein 4 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  18. NM_001384738.1NP_001371667.1  microtubule-associated protein 4 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  19. NM_001384744.1NP_001371673.1  microtubule-associated protein 4 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  20. NM_001384745.1NP_001371674.1  microtubule-associated protein 4 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  21. NM_001384746.1NP_001371675.1  microtubule-associated protein 4 isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  22. NM_001384748.1NP_001371677.1  microtubule-associated protein 4 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  23. NM_001384751.1NP_001371680.1  microtubule-associated protein 4 isoform 66

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  24. NM_001384752.1NP_001371681.1  microtubule-associated protein 4 isoform 106

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  25. NM_001384753.1NP_001371682.1  microtubule-associated protein 4 isoform 87

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  26. NM_001384754.1NP_001371683.1  microtubule-associated protein 4 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  27. NM_001384755.1NP_001371684.1  microtubule-associated protein 4 isoform 94

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  28. NM_001384756.1NP_001371685.1  microtubule-associated protein 4 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  29. NM_001384757.1NP_001371686.1  microtubule-associated protein 4 isoform 104

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  30. NM_001384758.1NP_001371687.1  microtubule-associated protein 4 isoform 100

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  31. NM_001384759.1NP_001371688.1  microtubule-associated protein 4 isoform 112

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  32. NM_001384760.1NP_001371689.1  microtubule-associated protein 4 isoform 120

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  33. NM_001384761.1NP_001371690.1  microtubule-associated protein 4 isoform 83

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  34. NM_001384762.1NP_001371691.1  microtubule-associated protein 4 isoform 127

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  35. NM_001384774.1NP_001371703.1  microtubule-associated protein 4 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  36. NM_001384776.1NP_001371705.1  microtubule-associated protein 4 isoform

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  37. NM_001384777.1NP_001371706.1  microtubule-associated protein 4 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  38. NM_001384778.1NP_001371707.1  microtubule-associated protein 4 isoform 122

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  39. NM_001384779.1NP_001371708.1  microtubule-associated protein 4 isoform 69

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  40. NM_001384780.1NP_001371709.1  microtubule-associated protein 4 isoform 84

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  41. NM_001384781.1NP_001371710.1  microtubule-associated protein 4 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  42. NM_001384782.1NP_001371711.1  microtubule-associated protein 4 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  43. NM_001384783.1NP_001371712.1  microtubule-associated protein 4 isoform 80

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  44. NM_001384784.1NP_001371713.1  microtubule-associated protein 4 isoform 132

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  45. NM_001384785.1NP_001371714.1  microtubule-associated protein 4 isoform 116

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  46. NM_001384786.1NP_001371715.1  microtubule-associated protein 4 isoform 58

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  47. NM_001384787.1NP_001371716.1  microtubule-associated protein 4 isoform 117

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  48. NM_001384788.1NP_001371717.1  microtubule-associated protein 4 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  49. NM_001384789.1NP_001371718.1  microtubule-associated protein 4 isoform 119

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  50. NM_001384790.1NP_001371719.1  microtubule-associated protein 4 isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  51. NM_001384791.1NP_001371720.1  microtubule-associated protein 4 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  52. NM_001384792.1NP_001371721.1  microtubule-associated protein 4 isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  53. NM_001384793.1NP_001371722.1  microtubule-associated protein 4 isoform 105

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  54. NM_001384794.1NP_001371723.1  microtubule-associated protein 4 isoform 82

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  55. NM_001384795.1NP_001371724.1  microtubule-associated protein 4 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  56. NM_001384796.1NP_001371725.1  microtubule-associated protein 4 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  57. NM_001384797.1NP_001371726.1  microtubule-associated protein 4 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  58. NM_001384798.1NP_001371727.1  microtubule-associated protein 4 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  59. NM_001384800.1NP_001371729.1  microtubule-associated protein 4 isoform 75

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  60. NM_001384802.1NP_001371731.1  microtubule-associated protein 4 isoform 128

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  61. NM_001384803.1NP_001371732.1  microtubule-associated protein 4 isoform 110

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  62. NM_001384804.1NP_001371733.1  microtubule-associated protein 4 isoform 73

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  63. NM_001384805.1NP_001371734.1  microtubule-associated protein 4 isoform 121

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  64. NM_001384806.1NP_001371735.1  microtubule-associated protein 4 isoform 71

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  65. NM_001384807.1NP_001371736.1  microtubule-associated protein 4 isoform 111

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  66. NM_001384808.1NP_001371737.1  microtubule-associated protein 4 isoform 129

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  67. NM_001384809.1NP_001371738.1  microtubule-associated protein 4 isoform 108

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  68. NM_001384810.1NP_001371739.1  microtubule-associated protein 4 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  69. NM_001384811.1NP_001371740.1  microtubule-associated protein 4 isoform 118

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  70. NM_001384812.1NP_001371741.1  microtubule-associated protein 4 isoform 133

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  71. NM_001384813.1NP_001371742.1  microtubule-associated protein 4 isoform 125

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  72. NM_001384814.1NP_001371743.1  microtubule-associated protein 4 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  73. NM_001384815.1NP_001371744.1  microtubule-associated protein 4 isoform 131

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  74. NM_001384816.1NP_001371745.1  microtubule-associated protein 4 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  75. NM_001384817.1NP_001371746.1  microtubule-associated protein 4 isoform 130

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  76. NM_001384819.1NP_001371748.1  microtubule-associated protein 4 isoform 76

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  77. NM_001384820.1NP_001371749.1  microtubule-associated protein 4 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  78. NM_001384824.1NP_001371753.1  microtubule-associated protein 4 isoform 59

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  79. NM_001384825.1NP_001371754.1  microtubule-associated protein 4 isoform 88

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  80. NM_001384826.1NP_001371755.1  microtubule-associated protein 4 isoform 113

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  81. NM_001384827.1NP_001371756.1  microtubule-associated protein 4 isoform 79

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  82. NM_001384828.1NP_001371757.1  microtubule-associated protein 4 isoform 57

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  83. NM_001384831.1NP_001371760.1  microtubule-associated protein 4 isoform 77

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  84. NM_001384832.1NP_001371761.1  microtubule-associated protein 4 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  85. NM_001384834.1NP_001371763.1  microtubule-associated protein 4 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  86. NM_001384835.1NP_001371764.1  microtubule-associated protein 4 isoform 134

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  87. NM_001384836.1NP_001371765.1  microtubule-associated protein 4 isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  88. NM_001384837.1NP_001371766.1  microtubule-associated protein 4 isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  89. NM_001384838.1NP_001371767.1  microtubule-associated protein 4 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  90. NM_001384839.1NP_001371768.1  microtubule-associated protein 4 isoform 89

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  91. NM_001384840.1NP_001371769.1  microtubule-associated protein 4 isoform 95

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  92. NM_001384841.1NP_001371770.1  microtubule-associated protein 4 isoform 102

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  93. NM_001384842.1NP_001371771.1  microtubule-associated protein 4 isoform 114

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  94. NM_001384843.1NP_001371772.1  microtubule-associated protein 4 isoform 72

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  95. NM_001384844.1NP_001371773.1  microtubule-associated protein 4 isoform 109

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  96. NM_001384845.1NP_001371774.1  microtubule-associated protein 4 isoform 101

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  97. NM_001384846.1NP_001371775.1  microtubule-associated protein 4 isoform 51

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  98. NM_001384847.1NP_001371776.1  microtubule-associated protein 4 isoform 67

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  99. NM_001384848.1NP_001371777.1  microtubule-associated protein 4 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  100. NM_001384849.1NP_001371778.1  microtubule-associated protein 4 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  101. NM_001384850.1NP_001371779.1  microtubule-associated protein 4 isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  102. NM_001384851.1NP_001371780.1  microtubule-associated protein 4 isoform 97

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  103. NM_001384853.1NP_001371782.1  microtubule-associated protein 4 isoform 85

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  104. NM_001384856.1NP_001371785.1  microtubule-associated protein 4 isoform 124

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  105. NM_001384857.1NP_001371786.1  microtubule-associated protein 4 isoform 90

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  106. NM_001384859.1NP_001371788.1  microtubule-associated protein 4 isoform 98

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  107. NM_001384861.1NP_001371790.1  microtubule-associated protein 4 isoform 115

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  108. NM_001384862.1NP_001371791.1  microtubule-associated protein 4 isoform 123

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  109. NM_001384863.1NP_001371792.1  microtubule-associated protein 4 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  110. NM_001384864.1NP_001371793.1  microtubule-associated protein 4 isoform 60

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  111. NM_001384866.1NP_001371795.1  microtubule-associated protein 4 isoform 99

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  112. NM_001384867.1NP_001371796.1  microtubule-associated protein 4 isoform 91

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  113. NM_001384868.1NP_001371797.1  microtubule-associated protein 4 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  114. NM_001384869.1NP_001371798.1  microtubule-associated protein 4 isoform 78

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  115. NM_001384870.1NP_001371799.1  microtubule-associated protein 4 isoform 93

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  116. NM_001384871.1NP_001371800.1  microtubule-associated protein 4 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  117. NM_001384872.1NP_001371801.1  microtubule-associated protein 4 isoform 68

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  118. NM_001384873.1NP_001371802.1  microtubule-associated protein 4 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  119. NM_001384874.1NP_001371803.1  microtubule-associated protein 4 isoform 64

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  120. NM_001384875.1NP_001371804.1  microtubule-associated protein 4 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  121. NM_001384876.1NP_001371805.1  microtubule-associated protein 4 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  122. NM_001384877.1NP_001371806.1  microtubule-associated protein 4 isoform 126

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  123. NM_001384878.1NP_001371807.1  microtubule-associated protein 4 isoform 96

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  124. NM_001384879.1NP_001371808.1  microtubule-associated protein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  125. NM_001384892.1NP_001371821.1  microtubule-associated protein 4 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  126. NM_001384893.1NP_001371822.1  microtubule-associated protein 4 isoform 103

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  127. NM_001385664.1NP_001372593.1  microtubule-associated protein 4 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  128. NM_001385665.1NP_001372594.1  microtubule-associated protein 4 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  129. NM_001385675.1NP_001372604.1  microtubule-associated protein 4 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  130. NM_001385676.1NP_001372605.1  microtubule-associated protein 4 isoform 107

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  131. NM_001385677.1NP_001372606.1  microtubule-associated protein 4 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  132. NM_001385681.1NP_001372610.1  microtubule-associated protein 4 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  133. NM_001385682.1NP_001372611.1  microtubule-associated protein 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  134. NM_001385684.1NP_001372613.1  microtubule-associated protein 4 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  135. NM_001385685.1NP_001372614.1  microtubule-associated protein 4 isoform 69

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  136. NM_001385686.1NP_001372615.1  microtubule-associated protein 4 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  137. NM_001385687.1NP_001372616.1  microtubule-associated protein 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  138. NM_001385688.1NP_001372617.1  microtubule-associated protein 4 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  139. NM_001385689.1NP_001372618.1  microtubule-associated protein 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  140. NM_001385690.1NP_001372619.1  microtubule-associated protein 4 isoform 135

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  141. NM_001385691.1NP_001372620.1  microtubule-associated protein 4 isoform 135

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  142. NM_001385692.1NP_001372621.1  microtubule-associated protein 4 isoform 135

    Status: REVIEWED

    Source sequence(s)
    AC124916, AC139667
  143. NM_002375.5NP_002366.2  microtubule-associated protein 4 isoform 1

    See identical proteins and their annotated locations for NP_002366.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).
    Source sequence(s)
    AA904866, AB209377, DA114613, M64571
    Consensus CDS
    CCDS33750.1
    UniProtKB/Swiss-Prot
    P27816
    Related
    ENSP00000353375.6, ENST00000360240.10
    Conserved Domains (1) summary
    pfam00418
    Location:9921021
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  144. NM_030885.4NP_112147.2  microtubule-associated protein 4 isoform 3

    See identical proteins and their annotated locations for NP_112147.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple exons in the 3' region and uses an unique splice site at the 3' end-exon compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AA206810, AI078534, BC051843, DA114613, DA150735
    Consensus CDS
    CCDS46821.1
    UniProtKB/Swiss-Prot
    P27816
    Related
    ENSP00000397414.1, ENST00000439356.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    47850695..48089272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006397.1XP_016861886.1  microtubule-associated protein 4 isoform X19

  2. XM_011533719.2XP_011532021.1  microtubule-associated protein 4 isoform X15

    Conserved Domains (1) summary
    pfam00418
    Location:10211050
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  3. XM_011533708.2XP_011532010.1  microtubule-associated protein 4 isoform X7

    Conserved Domains (1) summary
    pfam00418
    Location:21342163
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. XM_011533718.1XP_011532020.1  microtubule-associated protein 4 isoform X14

    Conserved Domains (2) summary
    pfam05086
    Location:19942152
    Dicty_REP; Dictyostelium (Slime Mold) REP protein
    pfam00418
    Location:21112140
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. XM_011533705.1XP_011532007.1  microtubule-associated protein 4 isoform X5

    Related
    ENSP00000407602.2, ENST00000426837.6
    Conserved Domains (1) summary
    pfam00418
    Location:21492178
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. XM_024453528.1XP_024309296.1  microtubule-associated protein 4 isoform X13

    Conserved Domains (3) summary
    pfam00418
    Location:21252154
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18422021
    Atrophin-1; Atrophin-1 family
  7. XM_024453527.1XP_024309295.1  microtubule-associated protein 4 isoform X12

    Conserved Domains (3) summary
    pfam00418
    Location:21252154
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18422021
    Atrophin-1; Atrophin-1 family
  8. XM_024453526.1XP_024309294.1  microtubule-associated protein 4 isoform X11

    Conserved Domains (3) summary
    pfam00418
    Location:21512180
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18432132
    Atrophin-1; Atrophin-1 family
  9. XM_017006391.1XP_016861880.1  microtubule-associated protein 4 isoform X4

  10. XM_011533704.2XP_011532006.1  microtubule-associated protein 4 isoform X3

    Conserved Domains (1) summary
    pfam00418
    Location:21512180
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  11. XM_017006392.1XP_016861881.1  microtubule-associated protein 4 isoform X10

  12. XM_011533709.2XP_011532011.1  microtubule-associated protein 4 isoform X9

    Conserved Domains (1) summary
    pfam00418
    Location:21282157
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  13. XM_024453525.1XP_024309293.1  microtubule-associated protein 4 isoform X8

    Conserved Domains (3) summary
    pfam00418
    Location:21662195
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18442093
    Atrophin-1; Atrophin-1 family
  14. XM_024453524.1XP_024309292.1  microtubule-associated protein 4 isoform X6

    Conserved Domains (3) summary
    pfam00418
    Location:21662195
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18442093
    Atrophin-1; Atrophin-1 family
  15. XM_011533703.2XP_011532005.1  microtubule-associated protein 4 isoform X2

    Conserved Domains (1) summary
    pfam00418
    Location:21662195
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  16. XM_024453523.1XP_024309291.1  microtubule-associated protein 4 isoform X1

    Conserved Domains (3) summary
    pfam00418
    Location:21972226
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18442093
    Atrophin-1; Atrophin-1 family
  17. XM_017006396.2XP_016861885.1  microtubule-associated protein 4 isoform X18

RNA

  1. XR_002959533.1 RNA Sequence

  2. XR_002959534.1 RNA Sequence

  3. XR_002959532.1 RNA Sequence

  4. XR_002959526.1 RNA Sequence

  5. XR_002959528.1 RNA Sequence

  6. XR_002959524.1 RNA Sequence

  7. XR_002959530.1 RNA Sequence

  8. XR_002959522.1 RNA Sequence

  9. XR_002959520.1 RNA Sequence

  10. XR_002959527.1 RNA Sequence

  11. XR_002959523.1 RNA Sequence

  12. XR_002959525.1 RNA Sequence

  13. XR_002959521.1 RNA Sequence

  14. XR_002959531.1 RNA Sequence

  15. XR_002959529.1 RNA Sequence

  16. XR_002959519.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134365.1: Suppressed sequence

    Description
    NM_001134365.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_030884.3: Suppressed sequence

    Description
    NM_030884.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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