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MAP4 microtubule associated protein 4 [ Homo sapiens (human) ]

Gene ID: 4134, updated on 4-Nov-2018

Summary

Official Symbol
MAP4provided by HGNC
Official Full Name
microtubule associated protein 4provided by HGNC
Primary source
HGNC:HGNC:6862
See related
Ensembl:ENSG00000047849 MIM:157132; Vega:OTTHUMG00000156828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in heart (RPKM 53.7), brain (RPKM 28.3) and 23 other tissues See more
Orthologs

Genomic context

See MAP4 in Genome Data Viewer
Location:
3p21.31
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (47850690..48089279, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47892180..48130769, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 Neighboring gene HIG1 domain family member 2A, mitochondrial pseudogene Neighboring gene DExH-box helicase 30 Neighboring gene microRNA 1226 Neighboring gene VPS26B pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 664, pseudogene Neighboring gene ribosomal protein L17 pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of microtubule-associated protein 4 (MAP4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of DNAL1 and MAP4 by siRNAs and shRNAs inhibits HIV-1 replication in HeLa P4.2 cells by blocking reverse transcription and 2-LTR formation PubMed
Knockdown of microtubule-associated protein 4 (MAP4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated microtubule-associated protein 4 (MAP4) is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with microtubule-associated protein 4 (MAP4) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8617, DKFZp779A1753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of spindle orientation IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule sliding IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
axoneme IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated protein 4
Names
MAP-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052840.1 RefSeqGene

    Range
    5001..243590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134364.1NP_001127836.1  microtubule-associated protein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA904866, AB209377, DA114613, DC343259
    Consensus CDS
    CCDS46818.1
    UniProtKB/Swiss-Prot
    P27816
    Related
    ENSP00000379083.3, OTTHUMP00000210726, ENST00000395734.7, OTTHUMT00000346090
    Conserved Domains (1) summary
    pfam00418
    Location:9921021
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. NM_002375.4NP_002366.2  microtubule-associated protein 4 isoform 1

    See identical proteins and their annotated locations for NP_002366.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).
    Source sequence(s)
    AA904866, AB209377, DA114613, DC343259, M64571
    Consensus CDS
    CCDS33750.1
    UniProtKB/Swiss-Prot
    P27816
    Related
    ENSP00000353375.6, OTTHUMP00000210722, ENST00000360240.10, OTTHUMT00000346085
    Conserved Domains (1) summary
    pfam00418
    Location:9921021
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  3. NM_030885.3NP_112147.2  microtubule-associated protein 4 isoform 3

    See identical proteins and their annotated locations for NP_112147.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple exons in the 3' region and uses an unique splice site at the 3' end-exon compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AA206810, AI078534, BC051843, DA114613, DA150735, DC343259
    Consensus CDS
    CCDS46821.1
    UniProtKB/Swiss-Prot
    P27816
    Related
    ENSP00000397414.1, OTTHUMP00000210723, ENST00000439356.2, OTTHUMT00000346087

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    47850690..48089279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006412.1XP_016861901.1  microtubule-associated protein 4 isoform X29

  2. XM_017006411.1XP_016861900.1  microtubule-associated protein 4 isoform X28

  3. XM_017006415.1XP_016861904.1  microtubule-associated protein 4 isoform X32

  4. XM_017006405.1XP_016861894.1  microtubule-associated protein 4 isoform X24

  5. XM_017006413.1XP_016861902.1  microtubule-associated protein 4 isoform X30

  6. XM_017006402.1XP_016861891.1  microtubule-associated protein 4 isoform X23

  7. XM_024453530.1XP_024309298.1  microtubule-associated protein 4 isoform X21

    Conserved Domains (2) summary
    pfam00418
    Location:10001029
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl26464
    Location:552896
    Atrophin-1; Atrophin-1 family
  8. XM_017006416.1XP_016861905.1  microtubule-associated protein 4 isoform X33

  9. XM_017006401.1XP_016861890.1  microtubule-associated protein 4 isoform X22

  10. XM_024453529.1XP_024309297.1  microtubule-associated protein 4 isoform X17

    Conserved Domains (2) summary
    pfam00418
    Location:10401069
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl26464
    Location:592936
    Atrophin-1; Atrophin-1 family
  11. XM_017006397.1XP_016861886.1  microtubule-associated protein 4 isoform X19

  12. XM_017006395.1XP_016861884.1  microtubule-associated protein 4 isoform X16

  13. XM_011533719.2XP_011532021.1  microtubule-associated protein 4 isoform X15

    Conserved Domains (1) summary
    pfam00418
    Location:10211050
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  14. XM_011533708.2XP_011532010.1  microtubule-associated protein 4 isoform X7

    Conserved Domains (1) summary
    pfam00418
    Location:21342163
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  15. XM_011533718.1XP_011532020.1  microtubule-associated protein 4 isoform X14

    Conserved Domains (2) summary
    pfam05086
    Location:19942152
    Dicty_REP; Dictyostelium (Slime Mold) REP protein
    pfam00418
    Location:21112140
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  16. XM_011533705.1XP_011532007.1  microtubule-associated protein 4 isoform X5

    Related
    ENSP00000407602.2, OTTHUMP00000210725, ENST00000426837.6, OTTHUMT00000346089
    Conserved Domains (1) summary
    pfam00418
    Location:21492178
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  17. XM_024453528.1XP_024309296.1  microtubule-associated protein 4 isoform X13

    Conserved Domains (3) summary
    pfam00418
    Location:21252154
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18422021
    Atrophin-1; Atrophin-1 family
  18. XM_024453527.1XP_024309295.1  microtubule-associated protein 4 isoform X12

    Conserved Domains (3) summary
    pfam00418
    Location:21252154
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18422021
    Atrophin-1; Atrophin-1 family
  19. XM_024453526.1XP_024309294.1  microtubule-associated protein 4 isoform X11

    Conserved Domains (3) summary
    pfam00418
    Location:21512180
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18432132
    Atrophin-1; Atrophin-1 family
  20. XM_017006391.1XP_016861880.1  microtubule-associated protein 4 isoform X4

  21. XM_011533704.2XP_011532006.1  microtubule-associated protein 4 isoform X3

    Conserved Domains (1) summary
    pfam00418
    Location:21512180
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  22. XM_017006392.1XP_016861881.1  microtubule-associated protein 4 isoform X10

  23. XM_011533709.2XP_011532011.1  microtubule-associated protein 4 isoform X9

    Conserved Domains (1) summary
    pfam00418
    Location:21282157
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  24. XM_024453525.1XP_024309293.1  microtubule-associated protein 4 isoform X8

    Conserved Domains (3) summary
    pfam00418
    Location:21662195
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18442093
    Atrophin-1; Atrophin-1 family
  25. XM_024453524.1XP_024309292.1  microtubule-associated protein 4 isoform X6

    Conserved Domains (3) summary
    pfam00418
    Location:21662195
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18442093
    Atrophin-1; Atrophin-1 family
  26. XM_011533703.2XP_011532005.1  microtubule-associated protein 4 isoform X2

    Conserved Domains (1) summary
    pfam00418
    Location:21662195
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  27. XM_024453523.1XP_024309291.1  microtubule-associated protein 4 isoform X1

    Conserved Domains (3) summary
    pfam00418
    Location:21972226
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl00062
    Location:93260
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl26464
    Location:18442093
    Atrophin-1; Atrophin-1 family
  28. XM_017006414.1XP_016861903.1  microtubule-associated protein 4 isoform X31

  29. XM_017006409.2XP_016861898.1  microtubule-associated protein 4 isoform X26

  30. XM_017006410.2XP_016861899.1  microtubule-associated protein 4 isoform X27

  31. XM_017006406.2XP_016861895.1  microtubule-associated protein 4 isoform X25

  32. XM_017006400.2XP_016861889.1  microtubule-associated protein 4 isoform X20

  33. XM_017006396.2XP_016861885.1  microtubule-associated protein 4 isoform X18

RNA

  1. XR_002959533.1 RNA Sequence

  2. XR_002959534.1 RNA Sequence

  3. XR_002959532.1 RNA Sequence

  4. XR_002959526.1 RNA Sequence

  5. XR_002959528.1 RNA Sequence

  6. XR_002959524.1 RNA Sequence

  7. XR_002959530.1 RNA Sequence

  8. XR_002959522.1 RNA Sequence

  9. XR_002959520.1 RNA Sequence

  10. XR_002959527.1 RNA Sequence

  11. XR_002959523.1 RNA Sequence

  12. XR_002959525.1 RNA Sequence

  13. XR_002959521.1 RNA Sequence

  14. XR_002959531.1 RNA Sequence

  15. XR_002959529.1 RNA Sequence

  16. XR_002959519.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134365.1: Suppressed sequence

    Description
    NM_001134365.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_030884.3: Suppressed sequence

    Description
    NM_030884.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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