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SdhCL Succinate dehydrogenase, subunit C-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41324, updated on 2-Nov-2024

Summary

Official Symbol
SdhCLprovided by FlyBase
Official Full Name
Succinate dehydrogenase, subunit C-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0037860
Locus tag
Dmel_CG6629
See related
AllianceGenome:FB:FBgn0037860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6629; Dmel\CG6629
Summary
Predicted to enable electron transfer activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Is expressed in adult head; spermatozoon; and testis. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See SdhCL in Genome Data Viewer
Location:
86D4-86D4; 3-50 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11114671..11115706, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6940393..6941428, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45579 Neighboring gene UDP-glycosyltransferase family 35 member C1 Neighboring gene Mitochondrial aconitase 2

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of respiratory chain complex II (succinate dehydrogenase) IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
succinate dehydrogenase, subunit C-like
Names
CG6629-PA
SdhCL-PA
NP_650041.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11114671..11115706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141784.2NP_650041.1  succinate dehydrogenase, subunit C-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650041.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGT9
    Related
    FBpp0081856, FBtr0082380
    Conserved Domains (1) summary
    cd03499
    Location:84201
    SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...