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Leash leash [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41320, updated on 6-Jul-2026
Official Symbol
Leashprovided by FlyBase
Official Full Name
leashprovided by FlyBase
Primary source
FLYBASE:FBgn0037856
Locus tag
Dmel_CG4674
See related
AllianceGenome:FB:FBgn0037856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32471; CG4674; Dmel\CG4674; leash
Summary
Predicted to enable ubiquitin protein ligase binding activity. Involved in positive regulation of hippo signaling. Located in cytoplasmic vesicle. Is expressed in organism. Orthologous to human ARRDC5 (arrestin domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Leash in Genome Data Viewer
Location:
86C7-86C7; 3-50 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10885540..10896418)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6711262..6722140)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Thiamine pyrophosphate carrier protein 1 Neighboring gene uncharacterized protein Neighboring gene Adenylate kinase 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45577 Neighboring gene long non-coding RNA:CR45578

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. ARRDC3 suppresses colorectal cancer progression through destabilizing the oncoprotein YAP. Shen X, et al. FEBS Lett, 2018 Feb. PMID 29364502
  2. RNAi screening comes of age: improved techniques and complementary approaches. Mohr SE, et al. Nat Rev Mol Cell Biol, 2014 Sep. PMID 25145850, Free PMC Article
  3. Upstairs, downstairs: spatial regulation of Hippo signalling. Fulford A, et al. Curr Opin Cell Biol, 2018 Apr. PMID 29154163
  4. The Hippo pathway uses different machinery to control cell fate and organ size. Pojer JM, et al. iScience, 2021 Aug 20. PMID 34355153, Free PMC Article
  5. A Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling. Zhao T, et al. Genetics, 2008 Feb. PMID 18245346, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
leash
Names
CG4674-PA
Leash-PA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10885540..10896418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141780.4 → NP_650037.2  leash

    See identical proteins and their annotated locations for NP_650037.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RII7, Q8SZ39, Q9VGU4
    Related
    FBpp0081801
    Conserved Domains (2) summary
    pfam02752
    Location:178 → 305
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:6 → 152
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SZ39 Q8SZ39
Q9VGU4 Q9VGU4

Gene LinkOut

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