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Cyp12e1 Cytochrome P450 12e1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41272, updated on 8-Feb-2025

Summary

Official Symbol
Cyp12e1provided by FlyBase
Official Full Name
Cytochrome P450 12e1provided by FlyBase
Primary source
FLYBASE:FBgn0037817
Locus tag
Dmel_CG14680
See related
AllianceGenome:FB:FBgn0037817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12e1; CG14680; Cyp12e; Cyp12E1; Dmel\CG14680
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See Cyp12e1 in Genome Data Viewer
Location:
86B4-86B4; 3-49 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10434789..10436704)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6260511..6262426)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rrp46 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44939 Neighboring gene long non-coding RNA:CR44955

Genomic regions, transcripts, and products

General protein information

Preferred Names
cytochrome P450 12e1
Names
CG14680-PC
Cyp12e1-PC
NP_650003.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10434789..10436704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141746.4NP_650003.4  cytochrome P450 12e1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650003.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V453, Q4V470, Q8INL9, Q9VGZ0
    Conserved Domains (1) summary
    cl12078
    Location:63517
    p450; Cytochrome P450