U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Timp Tissue inhibitor of metalloproteases [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41248, updated on 8-Feb-2025

Summary

Official Symbol
Timpprovided by FlyBase
Official Full Name
Tissue inhibitor of metalloproteasesprovided by FlyBase
Primary source
FLYBASE:FBgn0025879
Locus tag
Dmel_CG6281
See related
AllianceGenome:FB:FBgn0025879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6281; Dmel\CG6281; dTIMP; Dtimp; DTIMP; timp; TIMP; TIMP1
Summary
Enables metalloendopeptidase inhibitor activity. Involved in several processes, including imaginal disc-derived wing expansion; open tracheal system development; and ventral cord development. Located in dendrite. Is expressed in several structures, including adult head; adult heart; embryonic labial sensory complex; embryonic/larval dorsal vessel; and larval foregut atrium. Human ortholog(s) of this gene implicated in Moyamoya disease; Sorsby's fundus dystrophy; breast carcinoma; nephroblastoma; and urinary bladder cancer. Orthologous to several human genes including TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Timp in Genome Data Viewer
Location:
86A1-86A1; 3-49 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10203875..10213007, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6029597..6038729, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Bestrophin 1 Neighboring gene uncharacterized protein Neighboring gene Synapsin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in dendrite IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
tissue inhibitor of metalloproteases
Names
CG6281-PB
Timp-PB
tissue inhibitor of metalloproteinases

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10203875..10213007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169336.4NP_731461.1  tissue inhibitor of metalloproteases [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731461.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2N5, O96747, Q9VH14
    Related
    FBpp0081722
    Conserved Domains (1) summary
    pfam00965
    Location:26197
    TIMP; Tissue inhibitor of metalloproteinase