U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fancl fancl [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41231, updated on 4-Jan-2025

Summary

Official Symbol
Fanclprovided by FlyBase
Official Full Name
fanclprovided by FlyBase
Primary source
FLYBASE:FBgn0037781
Locus tag
Dmel_CG12812
See related
AllianceGenome:FB:FBgn0037781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12812; Dmel\CG12812; FAL; fancl; FANCL
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in DNA repair and protein monoubiquitination. Predicted to be part of Fanconi anaemia nuclear complex. Predicted to be active in nucleus. Is expressed in organism. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group L. Orthologous to human FANCL (FA complementation group L). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fancl in Genome Data Viewer
Location:
85F8-85F8; 3-49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10051508..10052869, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5877230..5878591, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial transcription factor B2 Neighboring gene uncharacterized protein Neighboring gene ohgata Neighboring gene antisense RNA:CR44192 Neighboring gene Niemann-Pick type C-2e Neighboring gene Niemann-Pick type C-2d

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
 
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Fanconi anaemia nuclear complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
fancl
Names
CG12812-PA
CG12812-PB
Fancl-PA
Fancl-PB

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10051508..10052869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300337.1NP_001287266.1  fancl, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287266.1

    Status: REVIEWED

    Conserved Domains (2) summary
    pfam09765
    Location:20293
    WD-3; WD-repeat region
    pfam11793
    Location:307375
    FANCL_C; FANCL C-terminal domain
  2. NM_141717.3NP_649974.1  fancl, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649974.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LH34, Q8T913, Q9VH34
    Related
    FBpp0081681
    Conserved Domains (4) summary
    pfam09765
    Location:1095
    WD-3; WD-repeat region
    pfam11793
    Location:307376
    FANCL_C; FANCL C-terminal domain
    pfam18890
    Location:110193
    FANCL_d2; FANCL UBC-like domain 2
    pfam18891
    Location:195293
    FANCL_d3; FANCL UBC-like domain 3