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MAN1A1 mannosidase alpha class 1A member 1 [ Homo sapiens (human) ]

Gene ID: 4121, updated on 19-Sep-2024

Summary

Official Symbol
MAN1A1provided by HGNC
Official Full Name
mannosidase alpha class 1A member 1provided by HGNC
Primary source
HGNC:HGNC:6821
See related
Ensembl:ENSG00000111885 MIM:604344; AllianceGenome:HGNC:6821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAN9; HUMM3; HUMM9
Summary
This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in fat (RPKM 62.7), liver (RPKM 46.9) and 25 other tissues See more
Orthologs
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Genomic context

See MAN1A1 in Genome Data Viewer
Location:
6q22.31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (119177205..119350605, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (120363405..120543535, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (119498370..119670926, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17507 Neighboring gene uncharacterized LOC124901389 Neighboring gene family with sequence similarity 184 member A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:119361669-119362560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17508 Neighboring gene MPRA-validated peak6067 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr6:119411357-119411858 Neighboring gene Sharpr-MPRA regulatory region 12550 Neighboring gene microRNA 548b Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17509 Neighboring gene ribosomal protein L13a pseudogene 15 Neighboring gene Sharpr-MPRA regulatory region 13895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17512 Neighboring gene RNA, U6 small nuclear 194, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25018 Neighboring gene uncharacterized LOC107986525 Neighboring gene uncharacterized LOC285762 Neighboring gene uncharacterized LOC105377975 Neighboring gene NANOG hESC enhancer GRCh37_chr6:119943697-119944198 Neighboring gene uncharacterized LOC105377972

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mannosidase, alpha, class 1A, member 1 (MAN1A1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
env HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex PubMed
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ20935

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mannosidase activity TAS
Traceable Author Statement
more info
PubMed 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Golgi apparatus mannose trimming TAS
Traceable Author Statement
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mannose trimming involved in glycoprotein ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein targeting to ER IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 

General protein information

Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Names
Man9-mannosidase
alpha-1,2-mannosidase IA
man(9)-alpha-mannosidase
processing alpha-1,2-mannosidase IA
NP_005898.2
XP_005267043.1
XP_011534135.1
XP_047274731.1
XP_054211415.1
XP_054211416.1
XP_054211417.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005907.4NP_005898.2  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

    See identical proteins and their annotated locations for NP_005898.2

    Status: REVIEWED

    Source sequence(s)
    AK025599, AL022722, BQ008013
    Consensus CDS
    CCDS5122.1
    UniProtKB/Swiss-Prot
    E7EU32, P33908, Q6P052, Q9NU44, Q9UJI3
    Related
    ENSP00000357453.3, ENST00000368468.4
    Conserved Domains (1) summary
    pfam01532
    Location:202640
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    119177205..119350605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266986.5XP_005267043.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

    Conserved Domains (1) summary
    pfam01532
    Location:285723
    Glyco_hydro_47; Glycosyl hydrolase family 47
  2. XM_011535833.3XP_011534135.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X2

    Conserved Domains (1) summary
    pfam01532
    Location:13451
    Glyco_hydro_47; Glycosyl hydrolase family 47
  3. XM_047418775.1XP_047274731.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    120363405..120543535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355440.1XP_054211415.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

  2. XM_054355441.1XP_054211416.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X2

  3. XM_054355442.1XP_054211417.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X3