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MAN1A1 mannosidase alpha class 1A member 1 [ Homo sapiens (human) ]

Gene ID: 4121, updated on 9-Dec-2018

Summary

Official Symbol
MAN1A1provided by HGNC
Official Full Name
mannosidase alpha class 1A member 1provided by HGNC
Primary source
HGNC:HGNC:6821
See related
Ensembl:ENSG00000111885 MIM:604344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAN9; HUMM3; HUMM9
Summary
This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in fat (RPKM 62.7), liver (RPKM 46.9) and 25 other tissues See more
Orthologs

Genomic context

See MAN1A1 in Genome Data Viewer
Location:
6q22.31
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (119177201..119350619, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (119498366..119671774, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184 member A Neighboring gene microRNA 548b Neighboring gene uncharacterized LOC107986526 Neighboring gene ribosomal protein L13a pseudogene 15 Neighboring gene RNA, U6 small nuclear 194, pseudogene Neighboring gene uncharacterized LOC105377973 Neighboring gene uncharacterized LOC107986525 Neighboring gene uncharacterized LOC285762

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mannosidase, alpha, class 1A, member 1 (MAN1A1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
env HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex PubMed
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20935

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
mannosidase activity TAS
Traceable Author Statement
more info
PubMed 
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Golgi apparatus mannose trimming TAS
Traceable Author Statement
more info
 
N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Names
Man9-mannosidase
alpha-1,2-mannosidase IA
man(9)-alpha-mannosidase
processing alpha-1,2-mannosidase IA
NP_005898.2
XP_005267043.1
XP_011534135.1
XP_011534136.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005907.4NP_005898.2  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

    See identical proteins and their annotated locations for NP_005898.2

    Status: REVIEWED

    Source sequence(s)
    AK025599, AL022722, BQ008013
    Consensus CDS
    CCDS5122.1
    UniProtKB/Swiss-Prot
    P33908
    Related
    ENSP00000357453.3, ENST00000368468.3
    Conserved Domains (1) summary
    pfam01532
    Location:202640
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    119177201..119350619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266986.4XP_005267043.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

    Conserved Domains (1) summary
    pfam01532
    Location:285723
    Glyco_hydro_47; Glycosyl hydrolase family 47
  2. XM_011535833.2XP_011534135.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X2

    Conserved Domains (1) summary
    pfam01532
    Location:13451
    Glyco_hydro_47; Glycosyl hydrolase family 47
  3. XM_011535834.3XP_011534136.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X3

    Conserved Domains (1) summary
    cl04955
    Location:285413
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

RNA

  1. XR_001743420.1 RNA Sequence

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