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Whamy WHAMM and JMY related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41198, updated on 4-Jan-2025

Summary

Official Symbol
Whamyprovided by FlyBase
Official Full Name
WHAMM and JMY relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0037750
Locus tag
Dmel_CG12946
See related
AllianceGenome:FB:FBgn0037750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12946; Dmel\CG12946; whamy
Summary
Enables small GTPase binding activity. Involved in several processes, including microtubule bundle formation; myoblast fusion; and positive regulation of supramolecular fiber organization. Located in lamellipodium; nucleus; and recycling endosome. Colocalizes with mitochondrion. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Whamy in Genome Data Viewer
Location:
85E8-85E8; 3-49 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9771795..9774419, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5597517..5600141, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 6 Neighboring gene N(alpha)-acetyltransferase 80 Neighboring gene uncharacterized protein Neighboring gene matotopetli Neighboring gene ncRNA Neighboring gene Ribosomal protein S29

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WHAMM and JMY related
Names
CG12946-PA
CG12946-PB
CG12946-PC
CG12946-PD
CG12946-PE
Whamy-PA
Whamy-PB
Whamy-PC
Whamy-PD
Whamy-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9771795..9774419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275506.1NP_001262435.1  WHAMM and JMY related, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262435.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYK0, Q9VH71
    Conserved Domains (1) summary
    pfam02205
    Location:442464
    WH2; WH2 motif
  2. NM_001275507.1NP_001262436.1  WHAMM and JMY related, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262436.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH08, Q8SYK0
    Conserved Domains (1) summary
    pfam02205
    Location:524546
    WH2; WH2 motif
  3. NM_001043234.2NP_001036699.1  WHAMM and JMY related, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036699.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI93, Q8SYK0
    Conserved Domains (1) summary
    pfam02205
    Location:558580
    WH2; WH2 motif
  4. NM_141687.1NP_649944.1  WHAMM and JMY related, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649944.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYK0, Q9VH71
    Related
    FBpp0081637, FBtr0082159
    Conserved Domains (1) summary
    pfam02205
    Location:442464
    WH2; WH2 motif
  5. NM_001275508.1NP_001262437.1  WHAMM and JMY related, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262437.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH08, Q8SYK0
    Conserved Domains (1) summary
    pfam02205
    Location:524546
    WH2; WH2 motif