Snap24 Synaptosomal-associated protein 24kDa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Snap24provided by FlyBase
Official Full Name: Synaptosomal-associated protein 24kDaprovided by FlyBase
Primary source: FLYBASE:FBgn0266720
Locus tag: Dmel_CG9474
See related: AllianceGenome:FB:FBgn0266720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9474; Dmel\CG9474; dSnap24; SNAP-24; SNAP-25b; snap24; SNAP24; Snap25b
Summary: Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in Golgi to plasma membrane transport; synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle priming. Located in secretory granule membrane. Colocalizes with secretory granule. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to several human genes including SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9761305..9763150, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5587027..5588872, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
colocalizes_with secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

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