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GstZ2 Glutathione S transferase Z2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41133, updated on 8-Feb-2025

Summary

Official Symbol
GstZ2provided by FlyBase
Official Full Name
Glutathione S transferase Z2provided by FlyBase
Primary source
FLYBASE:FBgn0037697
Locus tag
Dmel_CG9363
See related
AllianceGenome:FB:FBgn0037697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg9363; CG9363; Dmel\CG9363; gstz2; gstZ2; GSTZ2
Summary
Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrial matrix. Is expressed in adult head. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See GstZ2 in Genome Data Viewer
Location:
85D17-85D17; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9456815..9460652, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5282537..5286374, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pasilla Neighboring gene Glutathione S transferase Z1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45203 Neighboring gene phurba tashi

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables maleylacetoacetate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables maleylacetoacetate isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
glutathione S transferase Z2
Names
CG9363-PA
CG9363-PB
CG9363-PC
GstZ2-PA
GstZ2-PB
GstZ2-PC
NP_649895.1
NP_731358.1
NP_996190.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9456815..9460652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169286.2NP_731358.1  glutathione S transferase Z2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731358.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHD2
    Related
    FBpp0081519
    Conserved Domains (1) summary
    TIGR01262
    Location:10214
    maiA; maleylacetoacetate isomerase
  2. NM_206468.2NP_996190.1  glutathione S transferase Z2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996190.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHD2
    Conserved Domains (1) summary
    TIGR01262
    Location:5209
    maiA; maleylacetoacetate isomerase
  3. NM_141638.3NP_649895.1  glutathione S transferase Z2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649895.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H0RNF8, H8F4P9, Q8INN9, Q9VHD2
    Related
    FBpp0081520
    Conserved Domains (3) summary
    cd03191
    Location:104217
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cd03042
    Location:1690
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    TIGR01262
    Location:17221
    maiA; maleylacetoacetate isomerase