Format

Send to:

Choose Destination

MAGEB1 MAGE family member B1 [ Homo sapiens (human) ]

Gene ID: 4112, updated on 11-Jun-2021

Summary

Official Symbol
MAGEB1provided by HGNC
Official Full Name
MAGE family member B1provided by HGNC
Primary source
HGNC:HGNC:6808
See related
Ensembl:ENSG00000214107 MIM:300097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT3.1; DAM10; MAGEL1; MAGE-Xp
Summary
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 11.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MAGEB1 in Genome Data Viewer
Location:
Xp21.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (30243731..30252040)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (30261848..30270157)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member B2 Neighboring gene MAGE family member B3 Neighboring gene MAGE family member B4 Neighboring gene CRISPRi-validated cis-regulatory element chrX.504 Neighboring gene CRISPRi-validated cis-regulatory element chrX.505

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9322

General protein information

Preferred Names
melanoma-associated antigen B1
Names
DSS/AHC critical interval MAGE superfamily 10
MAGE-B1 antigen
MAGE-XP antigen
cancer/testis antigen 3.1
cancer/testis antigen family 3, member 1
melanoma antigen family B, 1
melanoma antigen family B1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016336.1 RefSeqGene

    Range
    5001..13310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002363.5NP_002354.2  melanoma-associated antigen B1

    See identical proteins and their annotated locations for NP_002354.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript.
    Source sequence(s)
    AC005185, DB022312, X82539
    Consensus CDS
    CCDS14222.1
    UniProtKB/Swiss-Prot
    P43366
    Related
    ENSP00000368264.3, ENST00000378981.8
    Conserved Domains (2) summary
    pfam01454
    Location:115283
    MAGE; MAGE family
    pfam12440
    Location:590
    MAGE_N; Melanoma associated antigen family N terminal
  2. NM_177404.3NP_796379.1  melanoma-associated antigen B1

    See identical proteins and their annotated locations for NP_796379.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three 5' exons but has an alternate 5' exon, as compared to variant 1. Variants 1, 2 and 3 all have the same last exon and encode the same protein.
    Source sequence(s)
    AC005185, BU166425
    Consensus CDS
    CCDS14222.1
    UniProtKB/Swiss-Prot
    P43366
    Related
    ENSP00000380681.2, ENST00000397548.4
    Conserved Domains (2) summary
    pfam01454
    Location:115283
    MAGE; MAGE family
    pfam12440
    Location:590
    MAGE_N; Melanoma associated antigen family N terminal
  3. NM_177415.3NP_803134.1  melanoma-associated antigen B1

    See identical proteins and their annotated locations for NP_803134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region, as compared to variant 1. Variants 1, 2 and 3 all have the same last exon and encode the same protein.
    Source sequence(s)
    AC005185, DB022312, X82539
    Consensus CDS
    CCDS14222.1
    UniProtKB/Swiss-Prot
    P43366
    Related
    ENSP00000380683.1, ENST00000397550.6
    Conserved Domains (2) summary
    pfam01454
    Location:115283
    MAGE; MAGE family
    pfam12440
    Location:590
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    30243731..30252040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center