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Srr Serine racemase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41117, updated on 8-Feb-2025

Summary

Official Symbol
Srrprovided by FlyBase
Official Full Name
Serine racemaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037684
Locus tag
Dmel_CG8129
See related
AllianceGenome:FB:FBgn0037684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8129; CT24308; Dmel\CG8129; sr; SR; stdh
Summary
Predicted to enable L-serine ammonia-lyase activity and serine racemase activity. Predicted to be involved in L-serine catabolic process. Is expressed in yolk nucleus. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See Srr in Genome Data Viewer
Location:
85D12-85D13; 3-48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9365398..9367763)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5191120..5193485)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene doctor no Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene FER tyrosine kinase Neighboring gene antisense RNA:CR46145 Neighboring gene Odorant receptor 85f

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine racemase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in L-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine racemase
Names
CG8129-PA
CG8129-PB
Srr-PA
Srr-PB
serine/threonine dehydratase
NP_649886.1
NP_731340.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9365398..9367763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141629.3NP_649886.1  serine racemase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649886.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHE9, Q9VHF0
    Related
    FBpp0081504
    Conserved Domains (3) summary
    cd01562
    Location:61364
    Thr-dehyd; Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly ...
    cd04886
    Location:385449
    ACT_ThrD-II-like; C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains
    PRK08198
    Location:58449
    PRK08198; threonine dehydratase; Provisional
  2. NM_169273.2NP_731340.1  serine racemase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731340.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KST5
    Related
    FBpp0081505
    Conserved Domains (2) summary
    cd04886
    Location:232296
    ACT_ThrD-II-like; C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains
    cl00342
    Location:1211
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...