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MAGEA11 MAGE family member A11 [ Homo sapiens (human) ]

Gene ID: 4110, updated on 11-Sep-2019

Summary

Official Symbol
MAGEA11provided by HGNC
Official Full Name
MAGE family member A11provided by HGNC
Primary source
HGNC:HGNC:6798
See related
Ensembl:ENSG00000185247 MIM:300344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT1.11; MAGE11; MAGE-11; MAGEA-11
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 1.8) See more
Orthologs

Genomic context

See MAGEA11 in Genome Data Viewer
Location:
Xq28
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (149688193..149717268)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (148769903..148798928)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 185A Neighboring gene FRAXF repeat instability region Neighboring gene MAGE family member A11 pseudogene Neighboring gene MAGE family member A10 pseudogene Neighboring gene MAGE family member A11 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
melanoma-associated antigen 11
Names
MAGE-11 antigen
cancer/testis antigen 1.11
cancer/testis antigen family 1, member 11
melanoma antigen family A, 11
melanoma antigen family A11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012803.1 RefSeqGene

    Range
    4957..34026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001011544.2NP_001011544.1  melanoma-associated antigen 11 isoform b

    See identical proteins and their annotated locations for NP_001011544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC244197, AI691089, BC004479, BX337921
    UniProtKB/Swiss-Prot
    P43364
    UniProtKB/TrEMBL
    G5E962
    Related
    ENSP00000328177.4, ENST00000333104.8
    Conserved Domains (2) summary
    pfam01454
    Location:214368
    MAGE; MAGE family
    pfam12440
    Location:86175
    MAGE_N; Melanoma associated antigen family N terminal
  2. NM_005366.5NP_005357.2  melanoma-associated antigen 11 isoform a

    See identical proteins and their annotated locations for NP_005357.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC244098, AI691089, BC004479, BQ212898
    Consensus CDS
    CCDS48180.1
    UniProtKB/Swiss-Prot
    P43364
    Related
    ENSP00000347358.5, ENST00000355220.6
    Conserved Domains (2) summary
    pfam01454
    Location:243397
    MAGE; MAGE family
    pfam12440
    Location:115204
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    149688193..149717268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029522.1XP_016885011.1  melanoma-associated antigen 11 isoform X2

    UniProtKB/Swiss-Prot
    P43364
    Conserved Domains (2) summary
    pfam01454
    Location:208362
    MAGE; MAGE family
    pfam12440
    Location:80169
    MAGE_N; Melanoma associated antigen family N terminal
  2. XM_011531164.2XP_011529466.1  melanoma-associated antigen 11 isoform X1

    Conserved Domains (2) summary
    pfam01454
    Location:235389
    MAGE; MAGE family
    pfam12440
    Location:107196
    MAGE_N; Melanoma associated antigen family N terminal
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