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Mcm2 Minichromosome maintenance 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40973, updated on 5-Aug-2022

Summary

Official Symbol
Mcm2provided by FlyBase
Official Full Name
Minichromosome maintenance 2provided by FlyBase
Primary source
FLYBASE:FBgn0014861
Locus tag
Dmel_CG7538
See related
AllianceGenome:FB:FBgn0014861
Gene type
protein coding
RNA name
minichromosome maintenance 2
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7538; dMcm2; dMCM2; Dmel\CG7538; DmeMCM2; DmMcm2; DmMCM2; l(3)rL074; mcm2; McM2; MCM2; mcm2-7; Mcm2-7; MCM2-7; MCM2_DROME; PCR3
Summary
Contributes to 3'-5' DNA helicase activity. Involved in chromosome condensation. Part of CMG complex and MCM complex. Is expressed in several structures, including central nervous system; extended germ band embryo; germ layer; posterior ectoderm anlage; and stage 5 embryo. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Mcm2 in Genome Data Viewer
Location:
84F6-84F6; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8264970..8267924)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4090692..4093646)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mind the gap Neighboring gene pseudo Neighboring gene Replication Protein A 70 Neighboring gene uncharacterized protein Neighboring gene atonal

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Mcm2 gene: The Mcm2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to 3'-5' DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CMG complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
minichromosome maintenance 2
Names
CG7538-PA
Mcm2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8264970..8267924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057773.4NP_477121.1  minichromosome maintenance 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477121.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49735, Q9VHU2
    Related
    FBpp0081317, FBtr0081827
    Conserved Domains (3) summary
    smart00350
    Location:276780
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:59166
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:182271
    MCM_N; MCM N-terminal domain