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Mcm2 Minichromosome maintenance 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40973, updated on 21-Oct-2020

Summary

Official Symbol
Mcm2provided by FlyBase
Official Full Name
Minichromosome maintenance 2provided by FlyBase
Primary source
FLYBASE:FBgn0014861
Locus tag
Dmel_CG7538
Gene type
protein coding
RNA name
minichromosome maintenance 2
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7538; dMcm2; dMCM2; Dmel\CG7538; DmeMCM2; DmMcm2; DmMCM2; l(3)rL074; mcm2; McM2; MCM2; mcm2-7; Mcm2-7; MCM2-7; MCM2_DROME; PCR3

Genomic context

See Mcm2 in Genome Data Viewer
Location:
84F6-84F6; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8264970..8267924)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4090692..4093646)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mind the gap Neighboring gene pseudo Neighboring gene Replication Protein A 70 Neighboring gene uncharacterized protein Neighboring gene atonal

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Mcm2 gene: The Mcm2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to 3'-5' DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA-dependent ATP-dependent DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
PubMed 
DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
minichromosome maintenance 2
Names
CG7538-PA
Mcm2-PA

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8264970..8267924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057773.4NP_477121.1  minichromosome maintenance 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477121.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49735
    Related
    FBpp0081317, FBtr0081827
    Conserved Domains (3) summary
    smart00350
    Location:276780
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:59166
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:184270
    MCM_N; MCM N-terminal domain
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