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MAFG MAF bZIP transcription factor G [ Homo sapiens (human) ]

Gene ID: 4097, updated on 7-Dec-2018

Summary

Official Symbol
MAFGprovided by HGNC
Official Full Name
MAF bZIP transcription factor Gprovided by HGNC
Primary source
HGNC:HGNC:6781
See related
Ensembl:ENSG00000197063 MIM:602020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hMAF
Summary
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 12.5), brain (RPKM 8.7) and 25 other tissues See more
Orthologs

Genomic context

See MAFG in Genome Data Viewer
Location:
17q25.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (81918269..81927711, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79876145..79885587, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene sirtuin 7 Neighboring gene MAFG divergent transcript Neighboring gene pyrroline-5-carboxylate reductase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13090, MGC20149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adult behavior IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular pH IEA
Inferred from Electronic Annotation
more info
 
regulation of epidermal cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor MafG
Names
basic leucine zipper transcription factor MafG
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002359.4NP_002350.1  transcription factor MafG

    See identical proteins and their annotated locations for NP_002350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA775797, AC145207, BC103722, DR156847
    Consensus CDS
    CCDS11793.1
    UniProtKB/Swiss-Prot
    O15525
    UniProtKB/TrEMBL
    A0A024R8X1
    Related
    ENSP00000350369.4, ENST00000357736.8
    Conserved Domains (1) summary
    cd14717
    Location:46115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
  2. NM_032711.3NP_116100.2  transcription factor MafG

    See identical proteins and their annotated locations for NP_116100.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA775797, AC145207, BC012327, BC103722
    Consensus CDS
    CCDS11793.1
    UniProtKB/Swiss-Prot
    O15525
    UniProtKB/TrEMBL
    A0A024R8X1
    Related
    ENSP00000376173.3, ENST00000392366.7
    Conserved Domains (1) summary
    cd14717
    Location:46115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    81918269..81927711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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