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Arl8 ADP ribosylation factor-like 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40961, updated on 8-Feb-2025

Summary

Official Symbol
Arl8provided by FlyBase
Official Full Name
ADP ribosylation factor-like 8provided by FlyBase
Primary source
FLYBASE:FBgn0037551
Locus tag
Dmel_CG7891
See related
AllianceGenome:FB:FBgn0037551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
arl8; BcDNA:LD29185; CG7891; Dmel\CG7891; Gie; Q9VHV5
Summary
Predicted to enable guanyl ribonucleotide binding activity and tubulin binding activity. Involved in several processes, including autophagosome-lysosome fusion; late endosome to lysosome transport; and presynapse assembly. Located in S bouton; cytoplasmic side of lysosomal membrane; and perinuclear region of cytoplasm. Is expressed in several structures, including adult head; adult heart; central brain primordium; embryonic central brain neurons; and ganglia. Orthologous to several human genes including ARL8B (ARF like GTPase 8B). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See Arl8 in Genome Data Viewer
Location:
84E13-84E13; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8126605..8129835)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3952327..3955557)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Asparagine-GTT 1-10 Neighboring gene transfer RNA:Arginine-ACG 1-6

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables alpha-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables beta-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in anterograde axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in late endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in S bouton IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasmic side of lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle midzone ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP ribosylation factor-like 8
Names
Arl8-PA
Arl8-PB
Arl8-PC
CG7891-PA
CG7891-PB
CG7891-PC
GTPase indispensable for equal segregation of chromosomes
novel GTPase indispensable for equal segregation of chromosomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8126605..8129835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300297.1NP_001287226.1  ADP ribosylation factor-like 8, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287226.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHV5
    UniProtKB/TrEMBL
    A0A0B4LGT4
    Conserved Domains (1) summary
    cd04159
    Location:22180
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases
  2. NM_001300296.1NP_001287225.1  ADP ribosylation factor-like 8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287225.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHV5
    UniProtKB/TrEMBL
    A0A0B4LGT4
    Conserved Domains (1) summary
    cd04159
    Location:22180
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases
  3. NM_141512.3NP_649769.1  ADP ribosylation factor-like 8, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649769.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHV5
    UniProtKB/TrEMBL
    A0A0B4LGT4
    Related
    FBpp0081290
    Conserved Domains (1) summary
    cd04159
    Location:22180
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases