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alpha-Est10 alpha-Esterase-10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40896, updated on 4-Jan-2025

Summary

Official Symbol
alpha-Est10provided by FlyBase
Official Full Name
alpha-Esterase-10provided by FlyBase
Primary source
FLYBASE:FBgn0015569
Locus tag
Dmel_CG1131
See related
AllianceGenome:FB:FBgn0015569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aE10; alpha-Ests; alphaE10; anon-WO0172774.144; CG1131; DmalphaE10; Dmel\CG1131; Esterase-10; K
Summary
Enables serine hydrolase activity. Is expressed in several structures, including adult head; embryonic/larval anterior midgut; embryonic/larval salivary gland; fat body; and nephrocyte. Orthologous to human CES3 (carboxylesterase 3) and CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See alpha-Est10 in Genome Data Viewer
Location:
84D8-84D9; 3-48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7486583..7493845, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3312305..3319567, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Valine-CAC 2-4 Neighboring gene small nuclear RNA 7SK a Neighboring gene alpha-Esterase-9 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial morphology and cristae structure 1 Neighboring gene alpha-Esterase-8

Genomic regions, transcripts, and products

General protein information

Preferred Names
alpha-Esterase-10
Names
CG1131-PB
CG1131-PC
CG1131-PD
Esterase-10
alpha-Est10-PB
alpha-Est10-PC
alpha-Est10-PD
fragment K
NP_001246962.1
NP_001246963.1
NP_524257.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7486583..7493845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260033.2NP_001246962.1  alpha-Esterase-10, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246962.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6L1, Q24204
    Conserved Domains (2) summary
    COG0657
    Location:132279
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:49542
    COesterase; Carboxylesterase family
  2. NM_079533.4NP_524257.3  alpha-Esterase-10, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524257.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24204, Q9I7L5
    Conserved Domains (2) summary
    COG0657
    Location:118265
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:35528
    COesterase; Carboxylesterase family
  3. NM_001260034.1NP_001246963.1  alpha-Esterase-10, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246963.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K604, Q24204
    Conserved Domains (2) summary
    COG0657
    Location:101248
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:18511
    COesterase; Carboxylesterase family