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MstProx MstProx [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40890, updated on 4-Jan-2025

Summary

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Official Symbol
MstProxprovided by FlyBase
Official Full Name
MstProxprovided by FlyBase
Primary source
FLYBASE:FBgn0015770
Locus tag
Dmel_CG1149
See related
AllianceGenome:FB:FBgn0015770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1149; Dmel\CG1149; DmMstProx; dTLR3; dToll3; mstprox; Mstprox; Tl-3; toll; Toll-3; Toll3
Summary
Predicted to enable signaling receptor activity. Involved in signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See MstProx in Genome Data Viewer
Location:
84D5-84D5; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7365939..7369305, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3191661..3195027, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Male-specific RNA 84Dc Neighboring gene Male-specific RNA 84Db Neighboring gene Male-specific RNA 84Da Neighboring gene long non-coding RNA:CR45560 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family. Mitcham JL, et al. J Biol Chem, 1996 Mar 8. PMID 8621445
  2. Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila. Levin TC, et al. Mol Biol Evol, 2017 Sep 1. PMID 28541576, Free PMC Article
  3. The Role of Toll and Nonnuclear NF-κB Signaling in the Response to Alcohol. Atkinson NS. Cells, 2023 May 30. PMID 37296629, Free PMC Article
  4. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Tauszig S, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973475, Free PMC Article
  5. Independent evolution of Toll and related genes in insects and mammals. Luo C, et al. Immunogenetics, 2000 Feb. PMID 10663571

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MstProx
Names
CG1149-PA
MstProx-PA
Toll-3
NP_649719.2
  • point mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7365939..7369305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141462.2 → NP_649719.2  MstProx [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649719.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24164, Q9NBK6, Q9VIA4
    Conserved Domains (2) summary
    smart00255
    Location:823 → 960
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:325 → 345
    LRR_1; leucine-rich repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JP25 Q7JP25
Q9NBK6 Q9NBK6
Q9VIA4 Q9VIA4

Gene LinkOut

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