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SMAD2 SMAD family member 2 [ Homo sapiens (human) ]

Gene ID: 4087, updated on 17-Sep-2017
Official Symbol
SMAD2provided by HGNC
Official Full Name
SMAD family member 2provided by HGNC
Primary source
HGNC:HGNC:6768
See related
Ensembl:ENSG00000175387 MIM:601366; Vega:OTTHUMG00000132652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2
Summary
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Orthologs
mouse all
Location:
18q21.1
Exon count:
18
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 18 NC_000018.10 (47833095..47931193, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (45359466..45457564, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372100 Neighboring gene thiopurine S-methyltransferase pseudogene 1 Neighboring gene mitochondrially encoded cytochrome c oxidase II pseudogene 2 Neighboring gene uncharacterized LOC105372101 Neighboring gene zinc finger and BTB domain containing 7C Neighboring gene uncharacterized LOC105372104 Neighboring gene RNA, U6 small nuclear 708, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Related articles in PubMed

  1. SMAD2 Mutations Are Associated with Arterial Aneurysms and Dissections. Micha D, et al. Hum Mutat, 2015 Dec. PMID 26247899
  2. Involvement of smad2 and Erk/Akt cascade in TGF-β1-induced apoptosis in human gingival epithelial cells. Yoshimoto T, et al. Cytokine, 2015 Sep. PMID 25882870
  3. High p-Smad2 expression in stromal fibroblasts predicts poor survival in patients with clinical stage I to IIIA non-small cell lung cancer. Chen Y, et al. World J Surg Oncol, 2014 Nov 5. PMID 25373709, Free PMC Article
  4. Ammonium chloride inhibits autophagy of hepatocellular carcinoma cells through SMAD2 signaling. Sun R, et al. Tumour Biol, 2015 Feb. PMID 25342595
  5. Overexpression of Smad2 inhibits proliferation of gingival epithelial cells. Shimoe M, et al. J Periodontal Res, 2014 Jun. PMID 23738652

See all (494) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. selective inhibition of SMAD3 or CCT6A efficiently suppresses TGF-beta-mediated metastasis. Findings provide a mechanism that directs TGF-beta signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta for non-small-cell lung carcinoma.
    Title: CCT6A suppresses SMAD2 and promotes prometastatic TGF-β signaling.
  2. In response to TGF-beta, RASSF1A is recruited to TGF-beta receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase ITCH. RASSF1A degradation is necessary to permit Hippo pathway effector YAP1 association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2.
    Title: TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation.
  3. Smad2 is a key scaffold, allowing RIN1 to act as a GTP exchange factor for MFN2-GTPase activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.
    Title: Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion.
  4. Ang down-regulate the expression of Col-I, alpha-SMA and TGF-beta1/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.
    Title: Angiotensin-(1-7) decreases the expression of collagen I via TGF-β1/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.
  5. The nuclear importin IPO5 was identified as a novel interacting protein of SMAD1. Overexpression of IPO5 in various cell lines specifically increases nuclear localization of BMP receptor-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 and BMP but not TGF-beta R-SMADs.
    Title: Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.
  6. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta/Smad2 signaling pathway, but not Smad1/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.
    Title: CD105 promotes chondrogenesis of synovium-derived mesenchymal stem cells through Smad2 signaling.
  7. the findings show that TIEG1 is highly expressed in human keloids and that it directly binds and represses Smad7 promoter-mediated activation of TGF-beta/Smad2 signaling
    Title: TIEG1 Represses Smad7-Mediated Activation of TGF-β1/Smad Signaling in Keloid Pathogenesis.
  8. A significant association was found between the low expression of inhibitory protein SMAD-7 and both zeta-chain-associated protein kinase 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1/8 and lower SMAD-4 expression in chronic lymphocytic leukemia cells
    Title: The distribution and potential prognostic value of SMAD protein expression in chronic lymphocytic leukemia.
  9. High expression of SMAD2 is associated with colorectal carcinoma.
    Title: Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-β1/Smad signaling pathway.
  10. this study shows that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2
    Title: Tolfenamic acid downregulates β-catenin in colon cancer.
Submit: New GeneRIF Correction See all GeneRIFs (234)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Replication interactions

Interaction Pubs
HIV-1 replication is restricted by TGFB1 and SMAD2 in Langerhans cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed
Tat tat HIV-1 Tat-treated pulmonary arterial smooth muscle cells downregulate levels of phosphorylated SMAD2/3 proteins and SMAD2/3-SMAD4 protein complex, which are repressed by cocaine exposure PubMed
tat HIV-1 Tat enhances binding of SMAD2, -3 and -4 and their binding partner Fast1 to the JCV DNA control region (CR) to stimulate JCV gene transcription in living cells PubMed

Go to the HIV-1, Human Interaction Database

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    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystem (from REACTOME)
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystemIn the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcrip...
  • Transcriptional regulation of pluripotent stem cells, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of pluripotent stem cells, organism-specific biosystemPluripotent stem cells are undifferentiated cells posessing an abbreviated cell cycle (reviewed in Stein et al. 2012), a characteristic profile of gene expression (Rao et al. 2004, Kim et al. 2006, P...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC22139, MGC34440

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
I-SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
R-SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
  
co-SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enhancer binding IC
Inferred by Curator
more info
 PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
  
phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
primary miRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
Inferred from Direct Assay
more info
 PubMed 
transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IDA
Inferred from Direct Assay
more info
 PubMed 
type I transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
SMAD protein complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
activin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
anterior/posterior pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
  
cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
  
common-partner SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
  
embryonic foregut morphogenesis IEA
Inferred from Electronic Annotation
more info
  
endoderm formation IEA
Inferred from Electronic Annotation
more info
  
gastrulation TAS
Traceable Author Statement
more info
 PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
insulin secretion IEA
Inferred from Electronic Annotation
more info
  
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
lung development IEA
Inferred from Electronic Annotation
more info
  
mesoderm formation ISS
Inferred from Sequence or Structural Similarity
more info
  
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
  
negative regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
  
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
  
nodal signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
organ growth IEA
Inferred from Electronic Annotation
more info
  
palate development ISS
Inferred from Sequence or Structural Similarity
more info
  
pancreas development IEA
Inferred from Electronic Annotation
more info
  
paraxial mesoderm morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
pericardium development IEA
Inferred from Electronic Annotation
more info
  
positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
  
positive regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
  
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
  
post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
primary miRNA processing TAS
Traceable Author Statement
more info
 PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
  
regulation of binding ISS
Inferred from Sequence or Structural Similarity
more info
  
regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
response to cholesterol IDA
Inferred from Direct Assay
more info
 PubMed 
response to glucose IEA
Inferred from Electronic Annotation
more info
  
signal transduction involved in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
somatic stem cell population maintenance TAS
Traceable Author Statement
more info
  
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
  
ureteric bud development IEA
Inferred from Electronic Annotation
more info
  
wound healing IEA
Inferred from Electronic Annotation
more info
  
zygotic specification of dorsal/ventral axis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
SMAD protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
SMAD2-SMAD3 protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
activin responsive factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
cytosol TAS
Traceable Author Statement
more info
  
nuclear chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
  
nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
protein complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
mothers against decapentaplegic homolog 2
Names
MAD homolog 2
SMAD, mothers against DPP homolog 2
Sma- and Mad-related protein 2
mother against DPP homolog 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029946.1 RefSeqGene

    Range
    5546..103050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003652.3 → NP_001003652.1  mothers against decapentaplegic homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001003652.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC120349, AI453799, BC025699, DB035686, DB462454
    Consensus CDS
    CCDS11934.1
    UniProtKB/Swiss-Prot
    Q15796
    UniProtKB/TrEMBL
    Q53XR6
    Related
    ENSP00000384449.1, OTTHUMP00000263823, ENST00000402690.6, OTTHUMT00000450571
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  2. NM_001135937.2 → NP_001129409.1  mothers against decapentaplegic homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001129409.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as SMAD2Deltaexon3) lacks an in-frame exon in the 5' coding region, compared to variant 2, resulting in an isoform (2) that is shorter than isoform 1. There are no publicly available full-length transcripts representing this variant, but it is supported by data in Taekenoshita et al. (1998; PMID: 9503010) and Yagi et al. (1999; PMID: 9873005).
    Source sequence(s)
    AC120349, AI453799, AK299218, DB035686, DB462454
    UniProtKB/TrEMBL
    B7Z5N5
    Related
    ENSP00000349282.4, ENST00000356825.8
    Conserved Domains (2) summary
    cd10491
    Location:8 → 142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236 → 426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  3. NM_005901.5 → NP_005892.1  mothers against decapentaplegic homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_005892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate exon (1b) in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC120349, AI453799, BC014840
    Consensus CDS
    CCDS11934.1
    UniProtKB/Swiss-Prot
    Q15796
    UniProtKB/TrEMBL
    Q53XR6
    Related
    ENSP00000262160.6, OTTHUMP00000163489, ENST00000262160.10, OTTHUMT00000255903
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p7 Primary Assembly

    Range
    47833095..47931193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025750.1 → XP_016881239.1  mothers against decapentaplegic homolog 2 isoform X7

    Conserved Domains (1) summary
    cd10985
    Location:26 → 216
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  2. XM_017025747.1 → XP_016881236.1  mothers against decapentaplegic homolog 2 isoform X4

  3. XM_006722451.3 → XP_006722514.1  mothers against decapentaplegic homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006722514.1

    UniProtKB/Swiss-Prot
    Q15796
    UniProtKB/TrEMBL
    Q53XR6
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  4. XM_017025748.1 → XP_016881237.1  mothers against decapentaplegic homolog 2 isoform X5

    Conserved Domains (2) summary
    cd10985
    Location:213 → 403
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:56 → 119
    MH1; N-terminal Mad Homology 1 (MH1) domain

  5. XM_017025746.1 → XP_016881235.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/Swiss-Prot
    Q15796
    Conserved Domains (2) summary
    cd10491
    Location:8 → 142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236 → 426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  6. XM_005258259.3 → XP_005258316.1  mothers against decapentaplegic homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005258316.1

    UniProtKB/Swiss-Prot
    Q15796
    UniProtKB/TrEMBL
    Q53XR6
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  7. XM_011525985.2 → XP_011524287.1  mothers against decapentaplegic homolog 2 isoform X5

    Conserved Domains (2) summary
    cd10985
    Location:213 → 403
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:56 → 119
    MH1; N-terminal Mad Homology 1 (MH1) domain

  8. XM_017025745.1 → XP_016881234.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    Q15796
    UniProtKB/TrEMBL
    Q53XR6
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  9. XM_011525984.2 → XP_011524286.1  mothers against decapentaplegic homolog 2 isoform X3

    Conserved Domains (2) summary
    cd10985
    Location:224 → 414
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:67 → 130
    MH1; N-terminal Mad Homology 1 (MH1) domain

  10. XM_017025749.1 → XP_016881238.1  mothers against decapentaplegic homolog 2 isoform X6

    Related
    ENSP00000466254.1, OTTHUMP00000263826, ENST00000587269.5, OTTHUMT00000450575

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    45354416..45452506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15796.1 GenPept UniProtKB/Swiss-Prot:Q15796

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