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Ece2 endothelin-converting enzyme 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 408243, updated on 1-May-2026
Official Symbol
Ece2provided by RGD
Official Full Name
endothelin-converting enzyme 2provided by RGD
Primary source
RGD:1303039
See related
Ensembl:ENSRNOG00000001715 AllianceGenome:RGD:1303039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. Orthologous to human EEF1AKMT4-ECE2 (EEF1AKMT4-ECE2 readthrough) and ECE2 (endothelin converting enzyme 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 59.3), Lung (RPKM 13.6) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Ece2 in Genome Data Viewer
Location:
11q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93767559..93782896, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80259130..80278446, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83948896..83985429, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4 gamma 1 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 2 Neighboring gene uncharacterized LOC102551589 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene EEF1A lysine methyltransferase 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization. Lorenzo MN, et al. Biochim Biophys Acta, 2001 Nov 11. PMID 11718899
  2. Opioid receptor function is regulated by post-endocytic peptide processing. Gupta A, et al. J Biol Chem, 2014 Jul 11. PMID 24847082, Free PMC Article
  3. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
  
involved_in cardioblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in heart development IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide hormone processing IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide hormone processing ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide hormone processing TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
endothelin-converting enzyme 2
NP_001002815.2
XP_038944491.1
XP_038944493.2
XP_038944494.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002815.2 → NP_001002815.2  endothelin-converting enzyme 2

    Status: VALIDATED

    Source sequence(s)
    BN000328, CB606217, JAXUCZ010000011
    UniProtKB/TrEMBL
    Q6IE65
    Related
    ENSRNOP00000091720.2, ENSRNOT00000119768.2
    Conserved Domains (2) summary
    cd08662
    Location:114 → 763
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:103 → 756
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    93767559..93782896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088565.2 → XP_038944493.2  endothelin-converting enzyme 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZM37
    Related
    ENSRNOP00000079117.2, ENSRNOT00000093894.2

  2. XM_039088563.2 → XP_038944491.1  endothelin-converting enzyme 2 isoform X1

    UniProtKB/TrEMBL
    Q6IE65
    Conserved Domains (1) summary
    cd08662
    Location:101 → 750
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

  3. XM_039088566.2 → XP_038944494.1  endothelin-converting enzyme 2 isoform X3

    Conserved Domains (1) summary
    pfam05649
    Location:116 → 502
    Peptidase_M13_N; Peptidase family M13
Nucleotide Protein Strain
Heading Accession and Version

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