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Prss57 serine protease 57 [ Rattus norvegicus (Norway rat) ]

Gene ID: 408241, updated on 6-Jul-2026
Official Symbol
Prss57provided by RGD
Official Full Name
serine protease 57provided by RGD
Primary source
RGD:1303330
See related
Ensembl:ENSRNOG00000025293 AllianceGenome:RGD:1303330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Df2; NSP4; Prssl1
Summary
Predicted to enable heparin binding activity and serine-type endopeptidase activity. Predicted to be involved in protein maturation and proteolysis. Predicted to be located in azurophil granule lumen. Predicted to be active in extracellular space. Orthologous to human PRSS57 (serine protease 57). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 1.9), Uterus (RPKM 0.5) and 5 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Prss57 in Genome Data Viewer
Location:
7q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10563477..10573617)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9915667..9922996)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479814 Neighboring gene mitotic spindle positioning Neighboring gene paralemmin Neighboring gene follistatin like 3 Neighboring gene ring finger protein 126

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease. Lin SJ, et al. Structure, 2014 Sep 2. PMID 25156428
  2. NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity. Perera NC, et al. J Immunol, 2013 Sep 1. PMID 23904161
  3. NSP4, an elastase-related protease in human neutrophils with arginine specificity. Perera NC, et al. Proc Natl Acad Sci U S A, 2012 Apr 17. PMID 22474388, Free PMC Article
  4. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in azurophil granule lumen ISO
Inferred from Sequence Orthology
more info
  
located_in azurophil granule lumen ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in organelle IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serine protease 57
Names
PRSSL1 homolog
complement factor D-like protein
neutrophil serine protease 4
protease, serine, 57
protease, serine-like 1
serine protease 1-like protein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003956.2 → NP_001003956.1  serine protease 57 precursor

    See identical proteins and their annotated locations for NP_001003956.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Conserved Domains (2) summary
    smart00020
    Location:33 → 203
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:34 → 214
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10563477..10573617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079725.2 → XP_038935653.1  serine protease 57 isoform X5

    Conserved Domains (1) summary
    cd00190
    Location:46 → 182
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_039079723.2 → XP_038935651.1  serine protease 57 isoform X3

    UniProtKB/TrEMBL
    A0A8L2UKW0
    Conserved Domains (1) summary
    cd00190
    Location:46 → 234
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_039079718.2 → XP_038935646.1  serine protease 57 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UKW0
    Conserved Domains (1) summary
    cd00190
    Location:46 → 270
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. XM_063264091.1 → XP_063120161.1  serine protease 57 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UKW0

  5. XM_063264089.1 → XP_063120159.1  serine protease 57 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UKW0

  6. XM_039079716.2 → XP_038935644.1  serine protease 57 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UKW0
    Conserved Domains (1) summary
    cd00190
    Location:46 → 270
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  7. XM_063264092.1 → XP_063120162.1  serine protease 57 isoform X2

    UniProtKB/Swiss-Prot
    Q6IE59
    UniProtKB/TrEMBL
    A0A8L2UKW0

  8. XM_006240979.5 → XP_006241041.1  serine protease 57 isoform X2

    See identical proteins and their annotated locations for XP_006241041.1

    UniProtKB/Swiss-Prot
    Q6IE59
    UniProtKB/TrEMBL
    A0A8L2UKW0
    Related
    ENSRNOP00000031690.5, ENSRNOT00000038553.5
    Conserved Domains (1) summary
    cd00190
    Location:34 → 258
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  9. XM_039079724.2 → XP_038935652.1  serine protease 57 isoform X4

    UniProtKB/TrEMBL
    A0A8L2UKW0
    Conserved Domains (1) summary
    cd00190
    Location:1 → 211
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IE59.2 GenPept UniProtKB/Swiss-Prot:Q6IE59

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