EDNRB endothelin receptor type B [Gallus gallus (chicken)] - Gene

Summary

Symbol: EDNRBprovided by CGNC
Full Name: endothelin receptor type Bprovided by CGNC
Primary source: CGNC:12695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (153874464..153888787)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (153811739..153826051)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We show that b-catenin is expressed during the pre-patterning of the epithelium prior to papilla induction and second that b-catenin, Ednrb and Inhba are expressed during the induction and patterning of the conjunctival papillae. Furthermore, we identified two genes, b-catenin and Prox1, that may be involved in the induction of the underlying scleral bones
Title: Gene expression analysis during the induction and patterning of the conjunctival papillae in the chick embryonic eye.
It is concluded that endothelin (ET) increase and ET receptor genes decrease are involved in the heart dysfunction of chickens with developmental pulmonary hypertension.
Title: Gene expression of endothelin-1 and its receptors in the heart of broiler chickens with T(3)-induced pulmonary hypertension.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables endothelin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: endothelin receptor type B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001127.2 → NP_001001127.1 endothelin receptor type B precursor

Status: VALIDATED

Source sequence(s)

AF472616, HAEK01026483, JAENSK010000027, MK359292

UniProtKB/TrEMBL

A0A7L4W6L5, Q8JHV4

Conserved Domains (1) summary

cd15976
Location:100 → 395

7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors