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EGF epidermal growth factor [ Gallus gallus (chicken) ]

Gene ID: 408035, updated on 3-Dec-2024

Summary

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Symbol
EGFprovided by CGNC
Full Name
epidermal growth factorprovided by CGNC
Primary source
CGNC:9223
See related
Ensembl:ENSGALG00010003806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See EGF in Genome Data Viewer
Location:
chromosome: 4
Exon count:
26
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (57538194..57597620, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (57541169..57600670, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110595 Neighboring gene ELOVL fatty acid elongase 6 Neighboring gene leucine rich repeat, Ig-like and transmembrane domains 3 Neighboring gene retinal pigment epithelium-derived rhodopsin homolog Neighboring gene GAR1 ribonucleoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium/protein kinase C and NFKB1. Ge C, et al. Biol Reprod, 2009 Mar. PMID 19005168
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EGF stimulated proliferation of chicken PGCs via activation of Ca(2+)/PKC involving NFKB1 signaling pathway.
    Title: Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium/protein kinase C and NFKB1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pro-epidermal growth factor
Names
epidermal growth factor (beta-urogastrone)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001292.2 → NP_001001292.2  pro-epidermal growth factor precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/TrEMBL
    A0A8V0XLN7, Q6PPB4
    Related
    ENSGALP00010005154.1, ENSGALT00010008810.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    57538194..57597620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046939964.1 → XP_046795920.1  pro-epidermal growth factor isoform X1

    UniProtKB/TrEMBL
    Q6PPB4

  2. XM_015276164.3 → XP_015131650.2  pro-epidermal growth factor isoform X2

    UniProtKB/TrEMBL
    Q6PPB4
    Conserved Domains (5) summary
    PHA03099
    Location:771 → 839
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    smart00135
    Location:450 → 492
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:696 → 737
    EGF_CA; Calcium-binding EGF-like domain
    pfam07645
    Location:738 → 769
    EGF_CA; Calcium-binding EGF domain
    cl00057
    Location:167 → 210
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RNA

  1. XR_005859117.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    57541169..57600670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915649.1 → XP_046771605.1  pro-epidermal growth factor isoform X1

    UniProtKB/TrEMBL
    Q6PPB4

  2. XM_046915651.1 → XP_046771607.1  pro-epidermal growth factor isoform X2

    UniProtKB/TrEMBL
    Q6PPB4

RNA

  1. XR_006934340.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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Research Materials