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CASP3 caspase 3 [ Bos taurus (domestic cattle) ]

Gene ID: 408016, updated on 5-Sep-2025
Official Symbol
CASP3provided by VGNC
Official Full Name
caspase 3provided by VGNC
Primary source
VGNC:VGNC:26781
See related
BGD:BT10404; EnsemblRapid:ENSBTAG00070011905
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See CASP3 in Genome Data Viewer
Location:
chromosome: 27
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (15047753..15072825, complement)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344048 Neighboring gene uncharacterized LOC104976051 Neighboring gene primase and DNA directed polymerase Neighboring gene centromere protein U Neighboring gene transfer RNA cysteine (anticodon GCA)

Genomic Sequence:
NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Active caspase-3 and ultrastructural evidence of apoptosis in spontaneous and induced cell death in bovine in vitro produced pre-implantation embryos. Gjørret JO, et al. Mol Reprod Dev, 2007 Aug. PMID 17393434
  2. Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage. Wu LM, et al. J Vet Sci, 2014 Dec. PMID 24962416, Free PMC Article
  3. Escherichia coli lipopolysaccharide administration transiently suppresses luteal structure and function in diestrous cows. Herzog K, et al. Reproduction, 2012 Oct. PMID 22829687
  4. The bovine mammary gland expresses multiple functional isoforms of serotonin receptors. Hernandez LL, et al. J Endocrinol, 2009 Oct. PMID 19654143, Free PMC Article
  5. Relationship between group II caspase activity of bovine preimplantation embryos and capacity for hatching. Jousan FD, et al. J Reprod Dev, 2008 Jun. PMID 18277054

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.
    Title: Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage.
  2. Data suggest that Escherichia coli infections (here, administration of LPS) provokes luteolysis in diestrus, non-lactating cows and up-regulation of expression of caspase 3 in corpus luteum but has no effect on luteinization in the following cycle.
    Title: Escherichia coli lipopolysaccharide administration transiently suppresses luteal structure and function in diestrous cows.
  3. Treatment of mammary epithelial cells with serotonin 1B and serotonin 2A receptor antagonists increased caspase-3 activity.
    Title: The bovine mammary gland expresses multiple functional isoforms of serotonin receptors.
  4. the capacity for blastocysts to undergo further development is related to degree of group II caspase activity
    Title: Relationship between group II caspase activity of bovine preimplantation embryos and capacity for hatching.
  5. mRNA expression of Bax, Bcl-2, caspase-3 and-7 cannot be used as a reliable apoptosis detection method.
    Title: mRNA expression of Bcl-2, Bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts.
  6. Data suggest that activation of caspase-3 is likely involved in both spontaneous and induced apoptosis in bovine pre-implantation embryos.
    Title: Active caspase-3 and ultrastructural evidence of apoptosis in spontaneous and induced cell death in bovine in vitro produced pre-implantation embryos.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
caspase-3
Names
CASP-3
caspase 3, apoptosis-related cysteine peptidase
NP_001071308.1
XP_010818547.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077840.1 → NP_001071308.1  caspase-3

    See identical proteins and their annotated locations for NP_001071308.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123503
    UniProtKB/Swiss-Prot
    Q08DY9
    UniProtKB/TrEMBL
    A0AAA9THN7
    Related
    ENSBTAP00070015993.1, ENSBTAT00070026855.1
    Conserved Domains (1) summary
    smart00115
    Location:37 → 275
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    15047753..15072825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010820245.4 → XP_010818547.1  caspase-3 isoform X1

    UniProtKB/TrEMBL
    A0AAA9THN7, F1MB04
    Conserved Domains (1) summary
    smart00115
    Location:39 → 277
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08DY9.1 GenPept UniProtKB/Swiss-Prot:Q08DY9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials